The effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients

Dwivedi, Ravi C; Dhindsa, Navjot; Krokhin, Oleg V; Cortens, John; Wilkins, John A; El-Gabalawy, Hani S

doi:10.1186/ar2637

Arthritis Research & Therapy

Table 2 Proteins with changes between week 12 and baseline identified in the responder and non-responder groups

From: The effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients

Protein name	Average ratio		Protein ID
	Responder	Non-responder
Anti-thrombin III variant	1.27	0.86	gi\|576554
Ceruloplasmin	0.80	0.95	gi\|1620909
Complement component 3	0.84	0.92	gi\|40786791
Complement component 5	0.89	0.94	gi\|38016947
Complement component 7 precursor	0.65	0.89	gi\|45580688
Complement factor H	0.82	1.06	gi\|56203410
Keratin 1	1.72	0.69	gi\|17318569
Keratin 2	1.60	0.70	gi\|47132620
ORM2	0.52	0.64	gi\|48145977
Orosomucoid 1	0.48	0.60	gi\|55958974
Plasminogen	0.85	0.91	gi\|56203917
Serum albumin precursor	0.72	1.18	gi\|6013427
Unnamed protein product	1.10	0.86	gi\|29581
Unnamed protein product	0.71	0.89	gi\|1335098
Angiotensinogen (ser [or cys]) proteinase inhibitor	1.19	ND	gi\|37790798
Anti-(ED-B) scFV	1.19	ND	gi\|3152364
Apolipoprotein A1	0.69	ND	gi\|4960066
C1 inhibitor	0.74	ND	gi\|29535
CarboNDypeptidase N polypeptide 1 50 kD	0.73	ND	gi\|55960072
Carnosinase 1	0.8	ND	gi\|21071039
Coagulation factor NDII-Mie	1.11	ND	gi\|24899162
Complement C1s	0.89	ND	gi\|6407558
Complement component 1, r subcomponent	0.82	ND	gi\|23243256
Complement component 2	0.87	ND	gi\|55961814
Cystatin C	1.51	ND	gi\|296643
Hypothetical protein	1.17	ND	gi\|51476334
Insulin-like growth factor-binding protein	0.81	ND	gi\|19344010
Inter-alpha-trypsin inhibitor heavy-chain H1	0.89	ND	gi\|825630
Keratin 10	1.91	ND	gi\|40354192
Leucine-rich alpha-2-glycoprotein 1	0.68	ND	gi\|47125362
PeroNDiredoNDin 2 isoform b	0.52	ND	gi\|33188452
Serpin peptidase inhibitor	0.83	ND	gi\|50659080
Serpin peptidase inhibitor, clade F	0.79	ND	gi\|21594846
SERPINC1 protein	0.75	ND	gi\|18490839
Transferrin	0.72	ND	gi\|37747855
Transthyretin	1.44	ND	gi\|48145933
Unnamed protein product	0.87	ND	gi\|29888
Vitamin D-binding protein precursor	0.88	ND	gi\|139641
Vitronectin	0.86	ND	gi\|14326449
Alpha1-anti-chymotrypsin	ND	1.06	gi\|1340142
Alpha-2-glycoprotein 1, zinc	ND	0.82	gi\|4502337
Apo-B100 precursor	ND	1.5	gi\|28780
Apolipoprotein H precursor	ND	0.9	gi\|4557327
Coagulation factor II precursor	ND	0.91	gi\|4503635
Complement component C8 beta chain precursor	ND	0.91	gi\|20141201
C-reactive protein	ND	1.39	gi\|30224
Hp2-alpha	ND	0.47	gi\|296653
IGHM protein	ND	1.37	gi\|49256421
Immunoglobulin kappa L chain VLJ region	ND	1.38	gi\|21669449
Mutant beta-globin	ND	1.29	gi\|18418633
Protein S alpha	ND	0.88	gi\|190442
SERPIND1	ND	0.84	gi\|47678677
Unnamed protein product	ND	0.88	gi\|28375497

All proteins had a greater than or equal to 95% confidence score for identification, P-value of less than or equal to 0.001 to 0.05, and an EF value of less than or equal to 2.0 and were present in two thirds of the patient group. ND, not determined. EF, error factor.

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ISSN: 1478-6362

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