Synovial fluid levels of collagen II turnover markers in inflamed joints. Synovial fluid concentrations of (a) collagenase-cleavage neoepitope of type II collagen (C2C) and (b) carboxypropeptide of type II collagen epitope (CPII) over time in inflamed intercarpal joints of horses (n = 6). Inflammation was induced at t = 0 by intra-articular injection of 0.5 ng Escherichia coli lipopolysaccharide. Data presented as the mean ± standard error of the mean. *P < 0.05, **P < 0.01, ***P < 0.001.