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Table 3 Linear regression analysis of S100A8 in 138 rheumatoid arthritis (RA) patients

From: Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis

Variable β SE t Pvalue 95% Confidence interval
Univariate analysis:      
   ACPA 2.23 0.27 8.34 < 0.001 1.70 to 2.76
   Age -0.03 0.01 -2.15 0.03 -0.06 to -0.002
   RF 2.21 0.26 8.33 < 0.001 1.68 to 2.73
   Carriage of HLA-DRB1*0401 1.05 0.32 3.26 0.001 0.41–1.69
   Carriage of RAGE 82S 0.83 0.40 2.07 0.04 0.04 to 1.62
   Carriage of shared epitope 0.94 0.36 2.63 0.01 0.23 to 1.66
   Joint space narrowinga 0.27 0.12 2.31 0.02 0.04 to 0.50
   S100A9a 0.48 0.13 3.65 < 0.001 0.22 to 0.75
   S100A12a 0.67 0.16 4.23 < 0.001 0.36 to 0.99
   sRAGEa -0.77 0.31 -2.51 0.01 -1.37 to -016
Multivariate analysis:      
   RF 1.45 0.28 5.12 < 0.001 0.89 to 2.01
   ACPA 1.22 0.29 4.24 < 0.001 0.65 to 1.79
   S100A9a 0.34 0.10 3.42 0.001 0.14 to 0.54
  1. Adjusted R2 of the multiple linear regression model = 0.49.
  2. aLogarithmic (base e) transformation.
  3. ACPA, anti-citrullinated peptide antibodies; HLA, human leukocyte antigen; RF, rheumatoid factor; (s)RAGE, (soluble) receptor for advanced glycation end products.