Table 3 Family-based association of the chromosome 4q27 gene region with rheumatoid arthritis: genotype relative risk
SNP | Genotype | RA cases (n) | Controls (n) | Odds ratio (95% confidence interval) | P value |
|---|---|---|---|---|---|
rs4505848 | GG | 38 | 51 | 0.72 (0.46 to 1.12) | 0.18 (GG vs. AA + AG) |
AG | 213 | 183 | 1.32 (1.01 to 1.72) | 0.04 (AG vs. GG + AA)a | |
AA | 182 | 199 | 0.85 (0.65 to 1.11) | 0.28 (AA vs. AG + GG) | |
rs11732095 | GG | 7 | 9 | 0.77 (0.28 to 2.09) | 0.8 (GG vs. AA + AG) |
AG | 87 | 101 | 0.83 (0.6 to 1.15) | 0.28 (AG vs. GG + AA) | |
AA | 340 | 324 | 1.23 (0.9 to 1.68) | 0.23 (AA vs. AG + GG) | |
rs6822844 | TT | 8 | 11 | 0.72 (0.29 to 1.81) | 0.64 (TT vs. GG + TG) |
TG | 99 | 110 | 0.87 (0.64 to 1.19) | 0.43 (TG vs. TT + GG) | |
GG | 327 | 313 | 1.18 (0.87 to 1.6) | 0.32 (GG vs. TT + TG) | |
rs4492018 | GG | 235 | 232 | 1.03 (0.79 to 1.35) | 0.89 (GG vs. AA + AG) |
AG | 174 | 171 | 1.03 (0.78 to 1.35) | 0.89 (AG vs. GG + AA) | |
AA | 25 | 31 | 0.79 (0.46 to 1.36) | 0.49 (AA vs. AG + GG) | |
rs1398553 | GG | 204 | 214 | 0.91 (0.7 to 1.19) | 0.54 (GG vs. AA + AG) |
AG | 195 | 175 | 1.2 (0.92 to 1.57) | 0.20 (AG vs. GG + AA) | |
AA | 35 | 45 | 0.77 (0.49 to 1.21) | 0.30 (AA vs. AG + GG) |