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Figure 2 | Arthritis Research & Therapy

Figure 2

From: RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro

Figure 2

Scanning EM analysis of the effect of CLO, ALN, and RANKL on the morphology of mature osteoclasts cultured in vitro. Rabbit osteoclasts were cultured on ivory discs for 24 hours with 50 μM CLO or 50 μM ALN, ± 100 ng/mL RANKL. (a) Control. (b) CLO. (c) CLO + RANKL. (d) ALN. (e) ALN + RANKL. Osteoclasts were fixed and processed for scanning EM analysis. Bars = 10 μm. ALN, 4-amino-1-hydroxy-butylidene-1,1-bisphosphonate (alendronate); CLO, dichloromethylene-1,1-bisphosphonate (clodronate); RANKL, receptor activator of nuclear factor-kappa-B ligand.

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Arthritis Research & Therapy

ISSN: 1478-6362

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