Dietary fatty acid intake affects the risk of developing bone marrow lesions in healthy middle-aged adults without clinical knee osteoarthritis: a prospective cohort study

Table 2 Relationship between fatty acid intake and incidence of bone marrow lesions

	Univariate analysis, OR (95% CI)	P value	Model 1 Multivariate analysis, OR (95% CI)^a	P value	Model 2 Multivariate analysis, OR (95% CI)^b	P value
Saturated fatty acids	1.08 (0.72–1.60)	0.73	2.62 (1.11–6.17)	0.03	2.56 (1.03–6.37)	0.04
Monounsaturated fatty acids	1.01 (0.66–1.52)	0.98	2.10 (0.81–5.47)	0.13	1.99 (0.75–5.31)	0.17
Polyunsaturated fatty acids	0.94 (0.62–1.42)	0.77	1.10 (0.64–1.90)	0.74	1.10 (0.62–1.96)	0.74
n-6 polyunsaturated fatty acids	0.88 (0.57–1.35)	0.55	0.98 (0.56–1.70)	0.93	0.98 (0.55–1.76)	0.96
n-3 polyunsaturated fatty acids	0.81 (0.53–1.25)	0.34	0.85 (0.46–1.56)	0.60	0.85 (0.45–1.61)	0.62
n-6/n-3 ratio	0.94 (0.63–1.38)	0.74	0.96 (0.65–1.41)	0.82	0.93 (0.61–1.42)	0.74

^aModel 1: odds ratio for development of tibiofemoral bone marrow lesions for each increase of 1 standard deviation in the respective fatty acid intake after adjusting for energy intake. ^bModel 2: odds ratio for development of tibiofemoral bone marrow lesions for each increase of 1 standard deviation in the respective fatty acid intake after adjusting for energy intake, age, gender, and body mass index. CI, confidence interval; OR, odds ratio.

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