Table 2 Genetic association between candidate single-nucleotide polymorphisms identified using DNA pooling in a cohort of Behçet's disease patients and controls
SNP (location) | Gene | Associated allele | Associated allele frequency | OR (95% CI) | P value | Permutation P value | HWE P value | |
|---|---|---|---|---|---|---|---|---|
Cases n (%) | Controls n (%) | |||||||
rs11206377 (1p34) | LOC100129342 | G | 189 (66.1) | 149 (51.4) | 1.84 (1.32–2.58) | 3.0 × 10-4 | 0.0036 | 0.89 |
rs12112050 (7p15) | CREB5 | T | 202 (67.8) | 187 (63.2) | 1.23 (0.87–1.72) | 0.24 | 0.93 | 0.75 |
rs2061634 (9q22) | KIAA1529 | G | 128 (42.7) | 79 (26.7) | 2.04 (1.45–2.88) | 4.2 × 10-5 | 0.0002 | 0.35 |
rs2875984 (8q12) | CHD7 | T | 61 (20.3) | 54 (18.6) | 1.12 (0.74–1.68) | 0.60 | 1 | 0.87 |
rs317711 (7p15-p14) | CPVL | C | 76 (25.5) | 39 (13.2) | 2.26 (1.47–3.45) | 1.0 × 10-4 | 0.0011 | 0.20 |
rs4936742 (11q24) | UBASH3B | T | 161 (56.7) | 125 (43.4) | 1.71 (1.23–2.38) | 1.5 × 10-3 | 0.0195 | 0.84 |
rs4949332 (1p35) | PUM1 | C | 162 (60.9) | 143 (53.0) | 2.38 (0.98–1.95) | 0.064 | 0.50 | 0.83 |
rs546550 (1p22-p21) | ABCA4 | A | 246 (84.8) | 230 (78.8) | 1.51 (0.98–2.31) | 0.058 | 0.47 | 0.13 |
rs6798232 (3q23) | PLS1 | G | 139 (46.3) | 125 (42.8) | 1.15 (0.83–1.60) | 0.39 | 0.99 | 0.68 |
rs9513584 (13q32) | UBAC2 | G | 128 (44.4) | 95 (33.2) | 1.61 (1.15–2.26) | 5.8 × 10-3 | 0.064 | 0.94 |