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Table 4 Comparison of SNP allele frequencies between SLE men and control men

From: Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study

  Minor allele frequency (%)a Mantel – Haenszel analysis
SNP (locus) SLE cases Controls OR (95% CI) P value
rs1143679 (ITGAM) 27.9 (83/298) 15.7 (181/1,154) 2.08 (1.5 to 2.8) 1.2 × 10-6
rs7574865 (STAT4) 31.7 (64/202) 21.5 (159/740) 1.69 (1.2 to 2.4) 0.0025
rs13277113 (C8orf13-BLK) 31.0 (88/284) 25.1 (267/1,064) 1.34 (1.0 to 1.8) 0.045
rs2304256 (TYK2) 26.8 (80/298) 28.8 (334/1,158) 0.91 (0.7 to 1.2) 0.5
rs17435 (MECP2)b 29.2 (42/144) 18.5 (105/568) 1.82 (1.2 to 2.8) 0.0046
rs10798269 (1q25.1) 28.0 (84/300) 30.7 (355/1,158) 0.88 (0.7 to 1.2) 0.4
rs17266594 (BANK1) 26.2 (56/214) 28.4 (227/798) 0.89 (0.6 to 1.3) 0.5
rs4963128 (KIAA1542) 28.0 (84/300) 34.9 (403/1,156) 0.73 (0.6 to 1.0) 0.025
rs6445975 (PXK) 32.1 (86/268) 24.8 (265/1,068) 1.43 (1.1 to 1.9) 0.016
rs509749 (LY9) 40.6 (121/298) 42.9 (496/1,156) 0.91 (0.7 to 1.2) 0.5
  1. Loci ordered as presented in Table 2. All results refer to the minor allele of each SNP, which is indicated in Table 1. No stratified analysis by sample collection was done due to the small number of patients with systemic lupus erythematosus (SLE) in each collection. CI, confidence interval; OR, odds ratio. aData presented as percentage (number of minor alleles/total number of alleles). bThese results are of carrier analysis because MECP2 is in the X chromosome and there is a single allele in each man.