Modulation of glucose transport by different extracellular glucose concentrations. 2-Deoxy-D-glucose (2-DG) uptake into normal (n = 6) and osteoarthritis (OA) (n = 9) chondrocytes cultured in media with 0 mM, 10 mM (regular glucose medium (RGM)) or 30 mM glucose (high glucose medium (HGM)) for 18 or 48 hours. Results expressed as the percentage relative to the respective control cells maintained in RGM. ***P < 0.001 relative to cells maintained in RGM, §§§P < 0.001 between normal and OA chondrocytes exposed to the same glucose concentration for the same period. Bars = mean ± standard deviation.