Figure 3

TNF blockade induces an increase in the frequency of peripheral blood total memory and pre-switch memory B cells, while reducing the circulating naïve B cells. (a) Box plots representing the 10th, 25th, 50th (median), 75th and 90th percentiles of the frequency of IgD⁺ CD27^- naïve B cells at the time of the 1st and 7th visits for the patients in the infliximab plus methotrexate (MTX) group (n = 15, grey bars) and MTX monotherapy (n = 8, white bars). (b) Box plots representing the 10th, 25th, 50th (median), 75th and 90th percentiles of the frequency of IgD⁺ CD27⁺ pre-switch memory B cells at the time of the 1st and 7th visits for the patients in the infliximab plus MTX group (n = 15, grey bars) and MTX monotherapy (n = 8, white bars). (c) Box plots representing the 10th, 25th, 50th (median), 75th and 90th percentiles of the frequency of IgD^- CD27⁺ post-switch memory B cells at the time of the 1st and 7th visits for the patients in the infliximab plus MTX group (n = 15, grey bars) and MTX monotherapy (n = 8, white bars). (d) Box plots representing the 10th, 25th, 50th (median), 75th and 90th percentiles of the frequency of total CD27⁺ memory B cells at the time of the 1st and 7th visits for the patients in the infliximab plus MTX group (n = 15, grey bars) and MTX monotherapy (n = 8, white bars). * Significant (P < 0.01) difference from 1st visit.