Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor

Table 2 Mutational frequencies of B cell subsets in peripheral blood from patients with rheumatoid arthritis

Population	Number of Sequences	Frequency (number) of mutated sequences	Mean (range) number of mutated nucleotides per mutated sequence	Overall mutational frequency	Mutational frequency for mutated sequences
CD19⁺ IgD⁺ CD27^-	92	24%^a (n = 22)	1.8 bp^a (1 to 5 bp)	1.7 × 10^-3a	7.3 × 10^-3a
CD19⁺ IgD⁺ CD27⁺	28	96% (n = 27)	12.3 bp (2 to 29 bp)	4.9 × 10^-2	5.1 × 10^-2

^a Significant difference (P < 0.05) between the CD19⁺ IgD⁺ CD27 and the CD19⁺ IgD⁺ CD27⁺ subsets.

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