Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Open Access

The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis

  • D Reviron1, 2, 3,
  • A Perdriger1, 2, 3,
  • E Toussirot1, 2, 3,
  • D Wendling1, 2, 3,
  • N Balandraud1, 2, 3,
  • S Guis1, 2, 3,
  • G Semana1, 2, 3,
  • P Tiberghien1, 2, 3,
  • P Mercier1, 2, 3 and
  • J Roudier1, 2, 3
Arthritis Research & Therapy20013(Suppl 2):P103

https://doi.org/10.1186/ar272

Received: 15 January 2001

Published: 26 January 2001

We propose to classify HLA-DRB1 alleles into 3 groups: shared epitope positive (SE), shared epitope negative with a positively charged HLA-DR P4 pocket (XP4p) and shared epitope negative with a negative or neutral HLA-DR XP4 pocket (XP4n). Using this classification to analyse 3 different French populations, we find that:

-SE/SE or SE/XP4p genotypes are associated with a high risk to develop RA.

-XP4p/XP4p or SE/XP4n genotypes are neutral

-XP4p/XP4p or XP4n/XP4n genotypes are protective with respect to the development of RA.

Authors’ Affiliations

(1)
INSERM EMI9940, Rheumatology Ward La Conception and EFS Histocompatibility
(2)
Rheumatology Ward and EFS Histocompatibility Rennes
(3)
Rheumatology Ward and EFS Histocompatibility

Copyright

© BioMed Central Ltd 2001

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