21st European Workshop for Rheumatology Research
- Meeting abstract
- Open Access
The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis
Arthritis Research & Therapy volume 3, Article number: P103 (2001)
We propose to classify HLA-DRB1 alleles into 3 groups: shared epitope positive (SE), shared epitope negative with a positively charged HLA-DR P4 pocket (XP4p) and shared epitope negative with a negative or neutral HLA-DR XP4 pocket (XP4n). Using this classification to analyse 3 different French populations, we find that:
-SE/SE or SE/XP4p genotypes are associated with a high risk to develop RA.
-XP4p/XP4p or SE/XP4n genotypes are neutral
-XP4p/XP4p or XP4n/XP4n genotypes are protective with respect to the development of RA.
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Reviron, D., Perdriger, A., Toussirot, E. et al. The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis. Arthritis Res Ther 3, P103 (2001) doi:10.1186/ar272
- Public Health
- High Risk
- Rheumatoid Arthritis
- Shared Epitope