Skip to main content

Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis

We propose to classify HLA-DRB1 alleles into 3 groups: shared epitope positive (SE), shared epitope negative with a positively charged HLA-DR P4 pocket (XP4p) and shared epitope negative with a negative or neutral HLA-DR XP4 pocket (XP4n). Using this classification to analyse 3 different French populations, we find that:

-SE/SE or SE/XP4p genotypes are associated with a high risk to develop RA.

-XP4p/XP4p or SE/XP4n genotypes are neutral

-XP4p/XP4p or XP4n/XP4n genotypes are protective with respect to the development of RA.

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Reviron, D., Perdriger, A., Toussirot, E. et al. The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis. Arthritis Res Ther 3, P103 (2001). https://doi.org/10.1186/ar272

Download citation

Keywords

  • Public Health
  • High Risk
  • Rheumatoid Arthritis
  • Arthritis
  • Shared Epitope