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Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Meeting abstract | Open | Published:

The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis

We propose to classify HLA-DRB1 alleles into 3 groups: shared epitope positive (SE), shared epitope negative with a positively charged HLA-DR P4 pocket (XP4p) and shared epitope negative with a negative or neutral HLA-DR XP4 pocket (XP4n). Using this classification to analyse 3 different French populations, we find that:

-SE/SE or SE/XP4p genotypes are associated with a high risk to develop RA.

-XP4p/XP4p or SE/XP4n genotypes are neutral

-XP4p/XP4p or XP4n/XP4n genotypes are protective with respect to the development of RA.

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Keywords

  • Public Health
  • High Risk
  • Rheumatoid Arthritis
  • Arthritis
  • Shared Epitope