21st European Workshop for Rheumatology Research
- Meeting abstract
- Published:
The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis
Arthritis Research & Therapy volume 3, Article number: P103 (2001)
We propose to classify HLA-DRB1 alleles into 3 groups: shared epitope positive (SE), shared epitope negative with a positively charged HLA-DR P4 pocket (XP4p) and shared epitope negative with a negative or neutral HLA-DR XP4 pocket (XP4n). Using this classification to analyse 3 different French populations, we find that:
-SE/SE or SE/XP4p genotypes are associated with a high risk to develop RA.
-XP4p/XP4p or SE/XP4n genotypes are neutral
-XP4p/XP4p or XP4n/XP4n genotypes are protective with respect to the development of RA.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Reviron, D., Perdriger, A., Toussirot, E. et al. The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis. Arthritis Res Ther 3 (Suppl 2), P103 (2001). https://doi.org/10.1186/ar272
Received:
Published:
DOI: https://doi.org/10.1186/ar272
Keywords
- Public Health
- High Risk
- Rheumatoid Arthritis
- Arthritis
- Shared Epitope