Positivity of HLA-DRB1 rheumatoid epitope does not predict the course of juvenile idiopathic arthritis in Czech children
© BioMed Central Ltd 2001
Received: 15 January 2001
Published: 26 January 2001
Association of juvenile idiopathic arthritis (JIA) with HLA class II still remains unresolved. Our study investigated whether presence of the HLA-DRB1 amino acid 70-74 rheumatoid epitope (RE) is a predictive factor of the disease course.
Patients and methods
We analysed 74 consecutive patients with JIA diagnosed and classified according to ILAR criteria, aged 11.2 ± 4.2 (mean ± SD), 35 boys and 39 girls. The numbers of children having oligoarticular, polyarticular, and systemic form of JIA were 24, 40, and 10, respectively. HLA-DRB1 alleles carrying the QRRAA, QKRAA, and RRRAA motifs of RE were typed for using PCR with sequence-specific primers.
Results and Conclusions
There were no significant differences in frequency of the RE, or its particular motifs, among the three forms of JIA.