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Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

In Marseille, Southern France, HLA-B2702 carries higher risk than HLA-B2705 to develop ankylosing spondylitis (AS)

HLA-B27 subtypes were defined by molecular typing in 45 patients with AS and 90 controls from Marseille. We subdivided patients and controls in 2 subgroups, according to the birth place of their grandparents: 19 patients and 38 controls constituted the Spanish/North African subgroup; 26 patients and 52 controls constituted the "French" subgroup. In patients from the Spanish/North African subgroup, the frequency of B2702 was higher (74%) than in controls from the same area (21%)pc<0.01 and the frequency of B2705 was lower in patients (25%) than in controls (79%) pc<0.01. In patients from the French group, the frequency of B2702 was higher (7%) than in controls (2%)(N.S.).

Thus, in the population of Southern France, B2702 seems to carry higher risk to develop AS than B2705.

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Guis, S., Nielsen, W., Boetsch, G. et al. In Marseille, Southern France, HLA-B2702 carries higher risk than HLA-B2705 to develop ankylosing spondylitis (AS). Arthritis Res Ther 3, P105 (2001). https://doi.org/10.1186/ar274

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Keywords

  • Public Health
  • High Risk
  • Ankylose Spondylitis
  • Spondylitis
  • Molecular Typing