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Arthritis Research & Therapy

Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Open Access

In Marseille, Southern France, HLA-B2702 carries higher risk than HLA-B2705 to develop ankylosing spondylitis (AS)

  • S Guis1,
  • W Nielsen1,
  • G Boetsch1,
  • O Dutour1,
  • P Mercier1,
  • D Reviron1 and
  • J Roudier1
Arthritis Research & Therapy20013(Suppl 2):P105

Received: 15 January 2001

Published: 26 January 2001


Public HealthHigh RiskAnkylose SpondylitisSpondylitisMolecular Typing

HLA-B27 subtypes were defined by molecular typing in 45 patients with AS and 90 controls from Marseille. We subdivided patients and controls in 2 subgroups, according to the birth place of their grandparents: 19 patients and 38 controls constituted the Spanish/North African subgroup; 26 patients and 52 controls constituted the "French" subgroup. In patients from the Spanish/North African subgroup, the frequency of B2702 was higher (74%) than in controls from the same area (21%)pc<0.01 and the frequency of B2705 was lower in patients (25%) than in controls (79%) pc<0.01. In patients from the French group, the frequency of B2702 was higher (7%) than in controls (2%)(N.S.).

Thus, in the population of Southern France, B2702 seems to carry higher risk to develop AS than B2705.

Authors’ Affiliations

Rheumatology Ward La Conception, INSERM EMI9940, EFS Alpes Provence Histocompatibility, Anthropology UMR6578, Marseille, France


© BioMed Central Ltd 2001