Degradome expression profiling in human articular cartilage

Table 4 Fold change and threshold cycle for cysteine proteases showing significant difference between OA and NOF

Gene name	Gene symbol	P value	Fold change OA/NOF	Median threshold cycle
Cathepsin K	CTSK	0.00005	5.2	26.0
Cathepsin Z	CTSZ	0.00005	2.9	25.4
Calpain 2	CAPN2	0.00006	2.0	25.5
Calpain 1	CAPN1	0.00008	2.0	27.5
Calpain 6	CAPN6	0.00008	6.8	30.9
Cathepsin O	CTSO	0.00008	2.4	28.2
Autophagin-2	AUTL2	0.00014	2.0	30.3
Cathepsin H	CTSH	0.00022	3.9	30.1
γ-Glutamyl hydrolase	GGH	0.00028	2.4	31.6
Cathepsin C	CTSC	0.00071	3.4	28.7
Bleomycin hydrolase	BLMH	0.00089	1.5	30.1
Ubiquitin-specific protease 19	USP19	0.00089	1.5	27.8
Ubiquitin-specific protease 18	USP18	0.00137	2.4	32.4
Cathepsin L	CTSL	0.00170	0.40	24.8
Ubiquitin-specific protease 13	USP13	0.00256	0.61	28.2
Calpain 5	CAPN5	0.00464	2.3	31.4
Ubiquitin-specific protease 37	USP37	0.00464	0.46	30.1
Caspase-8	CASP8	0.00561	1.5	30.0
Cathepsin F	CTSF	0.00561	1.8	25.7
Ubiquitin-specific protease 36	USP36	0.00561	0.56	29.3
Cathepsin W	CTSW	0.00677	2.1	34.6
Ubiquitin C-terminal hydrolase 3	UCHL3	0.00677	1.2	30.3
Ubiquitin-specific protease 28	USP28	0.00813	0.58	29.1
Caspase-2	CASP2	0.00974	1.2	28.6
hGPI8	PIGK	0.00974	1.9	27.8
Sentrin/SUMO protease 2	SENP2	0.00974	0.56	27.4

Fold change and median threshold cycle for all cysteine protease genes showing significant difference at P < 0.01 between osteoarthritis (OA) versus fracture to the neck of femur (NOF). P value from the Mann-Whitney U test. SUMO, small ubiquitin-like modifier.

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