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Table 4 Fold change and threshold cycle for cysteine proteases showing significant difference between OA and NOF

From: Degradome expression profiling in human articular cartilage

Gene name Gene symbol P value Fold change OA/NOF Median threshold cycle
Cathepsin K CTSK 0.00005 5.2 26.0
Cathepsin Z CTSZ 0.00005 2.9 25.4
Calpain 2 CAPN2 0.00006 2.0 25.5
Calpain 1 CAPN1 0.00008 2.0 27.5
Calpain 6 CAPN6 0.00008 6.8 30.9
Cathepsin O CTSO 0.00008 2.4 28.2
Autophagin-2 AUTL2 0.00014 2.0 30.3
Cathepsin H CTSH 0.00022 3.9 30.1
γ-Glutamyl hydrolase GGH 0.00028 2.4 31.6
Cathepsin C CTSC 0.00071 3.4 28.7
Bleomycin hydrolase BLMH 0.00089 1.5 30.1
Ubiquitin-specific protease 19 USP19 0.00089 1.5 27.8
Ubiquitin-specific protease 18 USP18 0.00137 2.4 32.4
Cathepsin L CTSL 0.00170 0.40 24.8
Ubiquitin-specific protease 13 USP13 0.00256 0.61 28.2
Calpain 5 CAPN5 0.00464 2.3 31.4
Ubiquitin-specific protease 37 USP37 0.00464 0.46 30.1
Caspase-8 CASP8 0.00561 1.5 30.0
Cathepsin F CTSF 0.00561 1.8 25.7
Ubiquitin-specific protease 36 USP36 0.00561 0.56 29.3
Cathepsin W CTSW 0.00677 2.1 34.6
Ubiquitin C-terminal hydrolase 3 UCHL3 0.00677 1.2 30.3
Ubiquitin-specific protease 28 USP28 0.00813 0.58 29.1
Caspase-2 CASP2 0.00974 1.2 28.6
hGPI8 PIGK 0.00974 1.9 27.8
Sentrin/SUMO protease 2 SENP2 0.00974 0.56 27.4
  1. Fold change and median threshold cycle for all cysteine protease genes showing significant difference at P < 0.01 between osteoarthritis (OA) versus fracture to the neck of femur (NOF). P value from the Mann-Whitney U test. SUMO, small ubiquitin-like modifier.