A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis

Table 3 Association of AR haplotype-tag polymorphisms and plasma hormone levels in the Nurses' Health Studies

AR SNP	Dehydroepiandrosterone sulfate^a	Total testosterone^b	Free testosterone^c
rs962458
CC	96.6 ± 12.6	23.2 ± 1.4	0.062 ± 0.003
CT/TT	98.5 ± 19.2	30.2 ± 3.4	0.081 ± 0.008
P value	0.91	0.06	0.03
rs6152
AA	84.7 ± 14.0	22.5 ± 1.5	0.060 ± 0.004
AG/GG	109.8 ± 14.4	28.8 ± 2.6	0.076 ± 0.006
P value	0.07	0.04	0.03
rs1204038
TT	86.7 ± 14.3	22.1 ± 1.5	0.059 ± 0.004
TC/CC	104.9 ± 13.8	27.4 ± 2.2	0.073 ± 0.006
P value	0.17	0.06	0.05
rs2361634
GG	97.1 ± 12.5	24.2 ± 1.4	0.064 ± 0.003
GA/AA	92.1 ± 19.1	24.3 ± 3.4	0.067 ± 0.008
P value	0.76	0.96	0.71
rs1337080
GG	96.4 ± 12.5	23.2 ± 1.4	0.061 ± 0.003
GA/AA	98.6 ± 19.1	30.2 ± 3.4	0.080 ± 0.008
P value	0.89	0.06	0.03
rs1337082
GG	87.1 ± 14.4	22.7 ± 1.8	0.060 ± 0.004
GA/AA	101.8 ± 13.2	25.4 ± 1.9	0.068 ± 0.005
P value	0.22	0.32	0.20

Androgen receptor gene (AR) association in 89 controls from the Nurses' Health Studies. Data presented as mean ± standard deviation. ^aAnalysis of covariance adjusted for age (continuous), body mass index (continuous), menopausal status and postmenopausal hormone use, cigarette smoking (never, past, current smoker <15 cigarettes per day, current smoker ≥ 15 cigarettes per day) and time of day of blood draw. ^bAnalysis of covariance adjusted for age (continuous), body mass index (continuous), menopausal status and postmenopausal hormone use, and cigarette smoking (never, past, current smoker <15 cigarettes per day, current smoker ≥ 15 cigarettes per day). ^cAnalysis of covariance adjusted for age (continuous), body mass index (continuous), menopausal status and postmenopausal hormone use, and cigarette smoking (never, past, current smoker <15 cigarettes per day, current smoker ≥ 15 cigarettes per day).

ISSN: 1478-6362