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Table 3 Association of AR haplotype-tag polymorphisms and plasma hormone levels in the Nurses' Health Studies

From: A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis

AR SNP Dehydroepiandrosterone sulfatea Total testosteroneb Free testosteronec
rs962458    
   CC 96.6 ± 12.6 23.2 ± 1.4 0.062 ± 0.003
   CT/TT 98.5 ± 19.2 30.2 ± 3.4 0.081 ± 0.008
   P value 0.91 0.06 0.03
rs6152    
   AA 84.7 ± 14.0 22.5 ± 1.5 0.060 ± 0.004
   AG/GG 109.8 ± 14.4 28.8 ± 2.6 0.076 ± 0.006
   P value 0.07 0.04 0.03
rs1204038    
   TT 86.7 ± 14.3 22.1 ± 1.5 0.059 ± 0.004
   TC/CC 104.9 ± 13.8 27.4 ± 2.2 0.073 ± 0.006
   P value 0.17 0.06 0.05
rs2361634    
   GG 97.1 ± 12.5 24.2 ± 1.4 0.064 ± 0.003
   GA/AA 92.1 ± 19.1 24.3 ± 3.4 0.067 ± 0.008
   P value 0.76 0.96 0.71
rs1337080    
   GG 96.4 ± 12.5 23.2 ± 1.4 0.061 ± 0.003
   GA/AA 98.6 ± 19.1 30.2 ± 3.4 0.080 ± 0.008
   P value 0.89 0.06 0.03
rs1337082    
   GG 87.1 ± 14.4 22.7 ± 1.8 0.060 ± 0.004
   GA/AA 101.8 ± 13.2 25.4 ± 1.9 0.068 ± 0.005
   P value 0.22 0.32 0.20
  1. Androgen receptor gene (AR) association in 89 controls from the Nurses' Health Studies. Data presented as mean ± standard deviation. aAnalysis of covariance adjusted for age (continuous), body mass index (continuous), menopausal status and postmenopausal hormone use, cigarette smoking (never, past, current smoker <15 cigarettes per day, current smoker ≥ 15 cigarettes per day) and time of day of blood draw. bAnalysis of covariance adjusted for age (continuous), body mass index (continuous), menopausal status and postmenopausal hormone use, and cigarette smoking (never, past, current smoker <15 cigarettes per day, current smoker ≥ 15 cigarettes per day). cAnalysis of covariance adjusted for age (continuous), body mass index (continuous), menopausal status and postmenopausal hormone use, and cigarette smoking (never, past, current smoker <15 cigarettes per day, current smoker ≥ 15 cigarettes per day).