Table 4 Associations of AR haplotypes, ESR2 haplotypes, PGR haplotypes, CYP19, block 1 haplotypes and RA risk

AR long-range haplotypes^c

   0-0-0-0-0-0

71.2

69.7

1.00 reference

1.00 reference

   0-1-1-0-0-1

8.1

8.1

0.98 (0.72 to 1.33)

0.99 (0.72 to 1.36)

   0-0-0-1-0-0

6.7

8.0

0.86 (0.62 to 1.19)

0.82 (0.58 to 1.14)

   1-1-1-0-1-1

6.4

5.3

1.19 (0.82 to 1.71)

1.29 (0.88 to 1.88)

   0-0-0-0-0-1

4.7

6.1

0.73 (0.50 to 1.07)

0.76 (0.51 to 1.12)

ESR2 haplotypes^d

   0-1-0-0-0

42.4

46.8

1.00

1.00

   1-0-0-1-0

27.2

24.7

1.16 (0.95 to 1.42)

1.15 (0.94 to 1.41)

   0-0-0-0-0

10.9

8.3

1.47 (1.07 to 2.01)

1.44 (1.05 to 1.98)

   0-0-0-1-0

9.1

9.6

0.99 (0.71 to 1.38)

0.91 (0.65 to 1.28)

PGR haplotypes^e

   0-0-0-0

41.2

37.5

1.00

1.00

   0-0-1-0

34.4

34.2

0.93 (0.75 to 1.14)

0.92 (0.75 to 1.14)

   0-0-0-1

13.1

16.3

0.72 (0.55 to 0.94)

0.73 (0.56 to 0.95)

   1-0-0-0

6.3

7.4

0.75 (0.53 to 1.06)

0.75 (0.53 to 1.07)

CYP19, block 1 haplotypes^f

   0-0-1-0-0-0

39.2

31.2

1.00

1.00

   0-0-0-1-1-0

14.0

14.4

0.68 (0.50 to 0.94)

0.71 (0.52 to 0.98)

   0-0-0-0-1-0

10.4

14.4

0.81 (0.61 to 1.08)

0.83 (0.62 to 1.11)

   0-0-0-0-0-0

10.3

9.6

0.69 (0.51 to 0.93)

0.71 (0.52 to 0.96)

   1-1-0-0-1-1

5.5

6.5

0.58 (0.38 to 0.88)

0.58 (0.38 to 0.88)