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Table 4 Associations of AR haplotypes, ESR2 haplotypes, PGR haplotypes, CYP19, block 1 haplotypes and RA risk

From: A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis

  Cases (%) Controls (%) Odds ratio (95% confidence interval)a Odds ratio (95% confidence interval)b
AR long-range haplotypesc     
   0-0-0-0-0-0 71.2 69.7 1.00 reference 1.00 reference
   0-1-1-0-0-1 8.1 8.1 0.98 (0.72 to 1.33) 0.99 (0.72 to 1.36)
   0-0-0-1-0-0 6.7 8.0 0.86 (0.62 to 1.19) 0.82 (0.58 to 1.14)
   1-1-1-0-1-1 6.4 5.3 1.19 (0.82 to 1.71) 1.29 (0.88 to 1.88)
   0-0-0-0-0-1 4.7 6.1 0.73 (0.50 to 1.07) 0.76 (0.51 to 1.12)
ESR2 haplotypesd     
   0-1-0-0-0 42.4 46.8 1.00 1.00
   1-0-0-1-0 27.2 24.7 1.16 (0.95 to 1.42) 1.15 (0.94 to 1.41)
   0-0-0-0-0 10.9 8.3 1.47 (1.07 to 2.01) 1.44 (1.05 to 1.98)
   0-0-0-1-0 9.1 9.6 0.99 (0.71 to 1.38) 0.91 (0.65 to 1.28)
PGR haplotypese     
   0-0-0-0 41.2 37.5 1.00 1.00
   0-0-1-0 34.4 34.2 0.93 (0.75 to 1.14) 0.92 (0.75 to 1.14)
   0-0-0-1 13.1 16.3 0.72 (0.55 to 0.94) 0.73 (0.56 to 0.95)
   1-0-0-0 6.3 7.4 0.75 (0.53 to 1.06) 0.75 (0.53 to 1.07)
CYP19, block 1 haplotypesf     
   0-0-1-0-0-0 39.2 31.2 1.00 1.00
   0-0-0-1-1-0 14.0 14.4 0.68 (0.50 to 0.94) 0.71 (0.52 to 0.98)
   0-0-0-0-1-0 10.4 14.4 0.81 (0.61 to 1.08) 0.83 (0.62 to 1.11)
   0-0-0-0-0-0 10.3 9.6 0.69 (0.51 to 0.93) 0.71 (0.52 to 0.96)
   1-1-0-0-1-1 5.5 6.5 0.58 (0.38 to 0.88) 0.58 (0.38 to 0.88)
  1. RA, rheumatoid arthritis. aConditional logistic regression, conditioning on matching factors. bConditional logistic regression, conditioning on matching factors and adjusting for cigarette smoking (never, past, current smoker <15 cigarettes per day, current smoker ≥ 15 cigarettes per day), age at menarche and parity. cAndrogen receptor gene (AR) haplotype-tagged SNPs: rs962458-rs6152-rs1204038-rs2361634-rs1337080-rs1337082. dEstrogen receptor 2 gene (ESR2) haplotype-tagged SNPs: rs3020450-rs1256031-rs1256049-rs4986938-rs944459. eProgesterone receptor gene (PGR) haplotype-tagged SNPs: rs518162-rs10895068-rs1379130-rs1042839. fAromatase gene (CYP19) block 1 haplotype-tagged SNPs: rs2446405-rs2445765-rs2470144-rs2445762-rs1004984-rs1902584; global haplotype association, P = 0.02.