Gene regulation | Early rheumatoid arthritis versus controls | P value | |
---|---|---|---|
Biological processes | |||
Up (cluster 2) | |||
Reverse transcription | 0.007 | ||
Amino acid activation | 0.01 | ||
Protein biosynthesisa | 0.02 | ||
Nucleoside, nucleotide, and nucleic acid metabolisma | 0.02 | ||
Protein metabolism and modification | 0.03 | ||
Other immune and defense | 0.04 | ||
Down (cluster 1) | |||
Granulocyte-mediated immunity | 0.0004 | ||
Other cell cycle process | 0.01 | ||
Macrophage-mediated immunity | 0.02 | ||
T cell-mediated immunity | 0.03 | ||
Other blood circulation and gas exchange activity | 0.04 | ||
Mitochondrial transport | 0.05 | ||
Molecular functions | |||
Up (cluster 2) | |||
Ribosomal proteina | 0.005 | ||
Reverse transcriptase | 0.007 | ||
Nucleic acid binding | 0.009 | ||
Other transcription factor | 0.03 | ||
Defense/immunity protein | 0.03 | ||
Nuclease | 0.04 | ||
Antibacterial response protein | 0.05 | ||
Down (cluster 1) | |||
Transmembrane receptor regulatory/adaptor protein | 0.008 | ||
Metalloprotease inhibitora | 0.02 | ||
Phosphorylase | 0.03 | ||
Protease inhibitor | 0.03 | ||
Cysteine protease inhibitor | 0.04 | ||
Pathways | |||
Up (cluster 2) | |||
Bupropion degradation | 0.007 | ||
Salvage pyrimidine deoxyribonucleotidesa | 0.01 | ||
Down (cluster 1) | |||
Metabotropic glutamide receptor group I pathway | 0.07 |