| | | |
Change in DAS or DAS28 attained
|
|---|
|
DAS or DAS28 attained at endpoint
|
> 1.2
|
0.6 < Δ ≤ 1.2
|
≤ 0.6
|
|---|
|
'High'
|
DAS > 3.7
|
DAS28 > 5.1
|
Moderate
| |
No
|
|
'Moderate'
|
2.4 < DAS ≤ 3.7
|
3.2 < DAS28 ≤ 5.1
|
Moderate
|
Moderate
| |
|
'Low'
|
DAS ≤ 2.4
|
DAS28 ≤ 3.2
|
Good
|
Moderate
| |
- Calculation of the disease activity scores DAS and DAS28 to assess joint inflammation in rheumatoid arthritis and the response criteria of the European League against Rheumatism (EULAR) [24–27]. The EULAR criteria use the level of disease activity at the endpoint as well as the change at the endpoint for determining a patient as a good, moderate or non-responder. DAS28 = 0.56 × (√TJC28) + 0.28 × (√SJC28) + 0.70 × (lnESR) + 0.014 × GH; DAS = 0.54 × (√RAI) + 0.065 × SJC44 + 0.33 × (lnESR) + 0.0072 × GH. DAS, Disease Activity Score; ESR, erythrocyte sedimentation rate; GH, general health; RAI, Ritchie Articular Index; SJC, swollen joint count; TJC, tender joint count.
