The determinants of susceptibility/resistance to adjuvant arthritis in rats

Table 2 Factors affecting susceptibility/resistance to adjuvant arthritis

Effector pathways/response	Susceptibility/resistance (+/-)	Rat strains tested	References
MHC and non-MHC genes including particular quantitative trait loci influence arthritis susceptibility	+/-	Table 1	Table 1, [4, 5]
Differential T-cell proliferative and/or cytokine response to Bhsp65, its arthritogenic epitope 180 to 188, or its regulatory C-terminal determinants	+/-	LEW/WKY/Wistar/F344	[20, 24, 30, 31, 33, 36]
Increased T-cell response to Rhsp65 and its regulatory epitopes	-	LEW/WKY	[20, 24, 26]
Anti-Bhsp65/Rhsp65 antibody response induced upon Mtb challenge	-	LEW/BN/WKY/F344/Wistar	[23, 25, 43]
Increased expression of hsp47 in the joints and enhanced anti-hsp47 antibodies in rats with arthritis	+	DA/AO	[45]
Immune response to hsp71	-	DA/AO/LEW	[45, 46]
Migration into and retention within the target organ (joints) of arthritogenic leukocytes; the role of monocyte chemoattractant protein 1 and monocyte/macrophage chemotaxis	+	LEW/WKY	[19, 20]
Increased reactive oxygen species contributing to arthritis resistance	-	DA/AO	[10]
Blunted hypothalamic–pituitary–adrenal axis activity	+	LEW/F344/Wistar	[51, 53–55]
Microbial flora in a conventional housing environment	-	F344/Wistar	[56, 59, 60]

Bhsp65, mycobacterial heat-shock protein 65; hsp, heat-shock protein; MHC, major histocompatibility complex; Mtb, Mycobacterium tuberculosis H37Ra; Rhsp65, rat heat-shock protein 65.

ISSN: 1478-6362