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Table 1 Proportion of RA and AITDs patients and controls with skewed X-chromosome inactivation

From: Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases

 

Number (%) observed with skewed

Degree of skewing (%)

RA (n = 76)

AITDs (n = 100)

Control females (n = 170)

90+

17 (22.4)

14 (14)

7 (4.1)

80 to 89

9 (11.8)

12 (12)

12 (7.1)

70 to 79

11 (14.5)

23 (23)

29 (17.1)

60 to 69

28 (36.8)

22 (22)

36 (21.2)

50 to 59

11 (14.5)

29 (29)

86 (50.6)

  1. For comparison by chi-squared P < 0.0001 and P = 0.0015 (> 80% skewing); P < 0.0001 and P = 0.0034 (90+% skewing) for patients with rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs), respectively.