Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases

Table 2 Characteristics of the patients with rheumatoid arthritis and skewed X-chromosome inactivation

Patient	Birth date	Disease onset	Pregnancy history	RF status	ACPA status	Other autoimmune disease	immunosuppressive therapy
90+% skewing
1	1949	48	G7, P4, A3	+	+	GSG	MXT
2	1954	42	G5, P4, A1	+	+	-	Plaquenil
3	1945	52	G7, P7, A0	-	-	GSG	-
4	1946	40	G3, P2, A1	+	-	-	-
5	1956	30	G2, P2, A0	-	-	-	-
6	1946	40	G3, P2, A1	-	+	GSG	-
7	1945	40	G4, P4, A0	+	-	-	-
8	1945	39	G5, P5, A0	-	+	-	-
9	1941	49	G7, P5, A2	+	+	-	MXT
10	1947	49	G4, P3, A1	+	-	GSG	-
11	1945	58	G4, P2, A1	-	+	GSG	MXT
12	1950	40	G3, P2, A1	+	+	GSG	MXT
13	1943	53	G3, P3, A0	+	-	-	-
14	1961	35	G2, P1, A1	+	-	-	-
15	1937	38	G4, P4, A0	-	-	-	-
16	1941	45	G5, P3, A1	+	+	-	-
17	1947	43	G3, P2, A0	-	+	GSG	-
80 to 89% skewing
18	1959	42	G5, P5, A0	+	+	-	MXT
19	1940	62	G0, P0, A0	-	-	-	-
20	1938	60	G9, P8, A1	+	+	GSG	MXT
21	1954	27	G0, P0, A0	+	+	GSG	-
22	1957	37	G5, P5, A0	+	+	GSG	-
23	1948	55	G9, P7, A0	+	-	-	MXT
24	1948	55	G0, P0, A0	-	-	-	-
25	1937	50	G3, P2, A1	-	+	GSG	-
26	1985	14	G0, P0, A0	+	-	-	-

A = spontaneous abortions; ACPA = anti-citrullinated protein/peptide antibodies; G = number of pregnancies; GSG = Sjögren's syndrome; MTX = methotrexate; P = para (pregnancies carried to term and delivered); RF = rheumatoid factor.

ISSN: 1478-6362