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Table 3 Association between baseline B-cell activation biomarkers and immunological features of the 578 patients with early rheumatoid arthritis

From: Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort

  IgM RF + IgM RF - P value Anti-CCP + Anti-CCP - P value
  n = 321 n = 257   n = 274 n = 304  
BAFF 0.7 (0.5–0.9) 0.7 (0.5–1.0) 0.18 0.7 (0.5–0.9) 0.7 (0.5–0.9) 0.18
Beta2–microglobulin 2.1 (1.8–2.4) 1.9 (1.6–2.3) 0.01 2.0 (1.7–2.4) 1.9 (1.6–2.4) 0.30
Total IgG 14.0 (12.0–16.9) 13.0 (11.1–15.1) <10-4 14.4 (12.4–17.1) 12.9 (11.1–15.9) <10-4
Total IgA 2.9 (2.1–3.7) 2.5 (1.9–3.3) <10-4 3.1 (2.3–3.8) 2.4 (1.8–3.2) <10-4
Total IgM 1.6 (1.2–2.2) 1.3 (1.1–1.8) <10-4 1.6 (1.2–2.3) 1.4 (1.0–1.9) <10-4
Kappa free light chain 15.8 (12.2–20.6) 12.7 (9.5–16.8) <10-4 16.3 (12.7–20.6) 12.7 (9.7–17.1) <10-4
Lambda free light chain 18.6 (14.4–25.0) 15.0 (11.8–19.6.) <10-4 19.3(14.9–24.9) 15.1 (11.9–19.9) <10-4
  1. Results are expressed as median values (25th–75th values). B-cell activating factor of the tumor necrosis factor family (BAFF) values are expressed in nanograms per milliliter, total immunoglobulin values in grams per liter, and free light chain of immunoglobulins in milligrams per liter. Comparisons used Mann-Whitney U test. Anti-CCP, anti-cyclic citrullinated peptide; RF, rheumatoid factor.