Table 2 Protein production of IL-6, MMP-1 and MMP-13 after a 72 hour incubation period on human osteoarthritic chondrocytes
|  | IL-6 (μg/mg protein) | MMP-1 (μg/mg protein) | MMP-13 (μg/mg protein) |
|---|---|---|---|
Control | 0.3 ± 0.1 | 12.7 ± 3.1 | 0.5 ± 0.1 |
IL-1β (100 pg/ml) | 3.6 ± 0.6 *(P < 0.002) | 62.7 ± 17.7 *(P < 0.02) | 3.5 ± 1.0 *(P < 0.01) |
IL-1β+ephrin B2 (50 ng/ml) | 2.2 ± 0.4 | 41.2 ± 5.7 | 1.9 ± 0.3 |
IL-1β+ephrin B2 (100 ng/ml) | 2.1 ± 0.4 †(P < 0.05) | 38.6 ± 5.5 | 2.0 ± 0.3 †(P = 0.05) |