Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Open Access

Time to lupus nephritis: impact of gender and ethnicity

  • VA Seligman1, 2,
  • H Li1, 2,
  • JL Olson1, 2 and
  • LA Criswell1, 2
Arthritis Research & Therapy20013(Suppl 2):P110

https://doi.org/10.1186/ar279

Received: 15 January 2001

Published: 26 January 2001

Objective

There is a paucity of literature regarding the time to development of nephritis among SLE patients. Our goal was to define this important parameter for a large multi-ethnic cohort, with an emphasis on the impact of gender and ethnicity.

Methods

779 SLE patients with disease satisfying the ACR criteria were classified as non-nephritis or definite nephritis patients based on questionnaire and comprehensive medical record review. Patients classified with definite nephritis fulfilled the criteria of proteinuria (> 0.5 g per 24 hrs), active sediment, or renal biopsy consistent with SLE. 716 (92%) were female. The ethnic distribution was: Caucasian 453 (58.2%), Hispanic 123 (15.8%), Asian 97 (12.4%), African American 75 (9.6%), and other 36 (4.6%). The annual rates of developing nephritis among different gender and ethnic subgroups were derived using Kaplan-Meier estimates.

Results

The table shows gender and ethnicity based Kaplan-Meier estimates of the proportion of patients with nephritis at designated time intervals. The curves are significantly different for males vs. females and Caucasians vs. non-Caucasians based on the log-rank test. The curves for Hispanic, Asian and African American subgroups did not differ significantly.
 

Proportion with nephritis at intervals after SLE diagnosis

 
 

1 year

2 years

3 years

5 years

10 years

P value *

Male

.47

.51

.51

.54

.57

 

Female

.20

.23

.24

.25

.30

8.16 × 10-7

Caucasian

.15

.17

.17

.18

.20

 

Non-Cauc

.33

.37

.40

.41

.49

6.23 × 10-14

* P value for log-rank test

Conclusions

These results are a significant contribution to the data regarding time to development of nephritis in SLE, and emphasize the important influence gender and ethnicity.

Authors’ Affiliations

(1)
Department of Medicine, UCSF
(2)
Department of Human Genetics, UCD

Copyright

© BioMed Central Ltd 2001

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