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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis

Figure 1

Expression and specific knock-down of heat shock protein 70 (Hsp70) in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs). Hsp70 was expressed in cultured RA FLSs as shown by reverse transcriptase-polymerase chain reaction (a) and Western blotting (b). Hsp70 levels were increased by tumor necrosis factor-alpha (TNF-α) treatment. Gene knock-down was specific for Hsp70; constitutional Hsp70 (Hsc70) levels were unaffected (c). The experiments were performed in RA FLSs from five patients and these are representative figures. GAPDH, glyceraldehyde-3-phosphate dehydrogenase; siRNA, small interfering RNA.

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Arthritis Research & Therapy

ISSN: 1478-6362

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