Extracellular matrix
| | | |
Aggrecan (ACAN)
|
[GenBank:X17406]
|
2.0
|
3.4 **
|
Asporin (ASPN)
|
[GenBank:NM_017680]
|
18.8 *
|
6.0 *
|
Biglycan (BGN)
|
[GenBank:NM_001711]
|
12.5
|
12.7 *
|
Cartilage intermediate layer protein 2 (CILP2)
|
[GenBank:BC034926]
|
78.2 *
|
71.3 *
|
Collagen, type II, alpha 1 (COL2A1)
|
[GenBank:X06268]
|
87.1
|
519.9 **
|
Collagen, type XI, alpha 1 (COL11A1)
|
[GenBank:BG028597]
|
10.4 **
|
5.9 *
|
Collagen, type IX, alpha 2 (COL9A2)
|
[GenBank:AI733465]
|
4.3
|
8.1
|
Cartilage link protein 1 (CRTL1)
|
[GenBank:NM_001884]
|
2.5
|
1.8
|
Cartilage oligomeric matrix protein (COMP)
|
[GenBank:NM_000095]
|
128.0 **
|
794.2 ***
|
Dermatopontin (DPT)
|
[GenBank:AL049798]
|
69.7 **
|
44.2 ***
|
Fibromodulin (FMOD)
|
[GenBank:NM_002023]
|
5.1
|
8.4 *
|
Fibronectin 1 (FN1)
|
[GenBank:AJ276395]
|
5.7 *
|
34.6 ***
|
TIMP metalloproteinase inhibitor 4 (TIMP4)
|
[GenBank:NM_003256]
|
14.1 *
|
25.4 *
|
Tenascin C (TNC)
|
[GenBank:BF434846]
|
3.3
|
3.5 *
|
Cell adhesion and receptors
| | | |
Epidermal growth factor receptor (EGFR)
|
[GenBank:AW157070]
|
-3.0 **
|
-1.9
|
Fibroblast growth factor receptor 2 (FGFR2)
|
[GenBank:NM_022969]
|
-7.4 *
|
-4.3
|
Laminin, alpha 2 (LAMA2)
|
[GenBank:AK026829]
|
5.7 *
|
4.8
|
Laminin, alpha 4 (LAMA4)
|
[GenBank:NM_002290]
|
-6.6 *
|
-8.6 **
|
Transforming growth factor, beta receptor I (TGFBR1)
|
[GenBank:AV700621]
|
4.2
|
20.0 ***
|
Thrombospondin 3 (THBS3)
|
[GenBank:L38969]
|
8.2 **
|
8.5 *
|
Growth factors
| | | |
Bone morphogenetic protein 1 (BMP1)
|
[GenBank:NM_001199]
|
2.1 *
|
1.8
|
Fibroblast growth factor 9 (FGF9)
|
[GenBank:NM_002010]
|
-9.0
|
-3.0
|
Insulin-like growth factor 1 (IGF1)
|
[GenBank:AI972496]
|
8.3
|
6.0
|
Insulin-like growth factor 2 (IGF2)
|
[GenBank:X07868]
|
114.9 **
|
43.5 **
|
Transforming growth factor, beta 1 (TGFB1)
|
[GenBank:BC000125]
|
3.0 *
|
2.4 *
|
Transcription factors
| | | |
Distal-less homeobox 5 (DLX5)
|
[GenBank:NM_005221]
|
5.1 *
|
25.6 *
|
Homeobox A11 (HOXA11)
|
[GenBank:H94842]
|
6.5
|
2.3 *
|
Homeobox A13 (HOXA13)
|
[GenBank:BG289306]
|
5.2
|
2.0
|
Runt-related transcription factor 2 (RUNX2)
|
[GenBank:AL353944]
|
4.0
|
4.2 *
|
SIX homeobox 1 (SIX1)
|
[GenBank:N79004]
|
1.6 *
|
1.3
|
SIX homeobox 4 (SIX4)
|
[GenBank:AI554514]
|
1.8
|
2.3
|
SRY (sex determining region Y)-box 9 (SOX9)
|
[GenBank:NM_000346]
|
4.4 **
|
11.8 **
|
Wingless-type MMTV integration site family, member 5B (WNT5B)
|
[GenBank:AW007350]
|
3.0
|
7.0
|
Enzymes
| | | |
ADAM metalloproteinase with thrombospondin type 1 motif, 12 (ADAMTS12)
|
[GenBank:W74476]
|
-13.7 **
|
-2.4
|
ADAM metalloproteinase with thrombospondin type 1 motif, 2 (ADAMTS2)
|
[GenBank:NM_021599]
|
3.1
|
4.7 **
|
ADAM metalloproteinase with thrombospondin type 1 motif, 5 (ADAMTS5)
|
[GenBank:BF060767]
|
-8.8 *
|
-7.6 **
|
Matrix metalloproteinase 1 (MMP1)
|
[GenBank:NM_002421]
|
-10.6 **
|
-59.7
|
Matrix metalloproteinase 2 (MMP2)
|
[GenBank:NM_004530]
|
1.9 *
|
3.4 *
|
Matrix metalloproteinase 7 (MMP7)
|
[GenBank:NM_002423]
|
109.7 ***
|
107.2 **
|