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Table 4 Genes differentially expressed comparing chondrocytes in culture obtained from osteoarthritic (OA) and normal donors (ND)

From: Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation

Functional annotation Gene title (Gene symbol) Accession number Fold change Signal
   OA vs ND OA ND
Monolayer     
ADAM metalloproteinase with thrombospondin type 1 motif, 1 (ADAMTS1) [GenBank:AF060152] -1.7 968.0 1925.2
Collagen, type III, alpha 1 (COL3A1) [GenBank:AU146808] 2.2 564.3 258.7
Collagen, type V, alpha 3 (COL5A3) [GenBank:AI984221] 2.9 977.6 392.1
Collagen, type XI, alpha 1 (COL11A1) [GenBank:BG028597] 1.9 327.8 161.1
Cartilage link protein 1 (HAPLN1) [GenBank:NM_001884] 1.8 * 2640.7 1467.5
Cartilage oligomeric matrix protein (COMP) [GenBank:NM_000095] -6.1 * 24.7 187.4
Dystonin (DST) [GenBank:BC004912] -2.0 729.4 1486.6
Fibronectin 1 (FN1) [GenBank:AJ276395] -3.1 441.9 1642.6
Matrix metalloproteinase 1 (MMP1) [GenBank:NM_002421] 5.0 * 857.0 200.5
Matrix metalloproteinase 2 (MMP2) [GenBank:NM_004530] -1.9 2300.1 3706.1
Matrix metalloproteinase 3 (MMP3) [GenBank:NM_002422] 2.6 2496.8 1052.8
Periostin, osteoblast specific factor (POSTN) [GenBank:AY140646] 1.9 6610.8 3544.5
SRY (sex determining region Y)-box 9 (SOX9) [GenBank:AI382146] -2.6 * 123.0 281.2
Transforming growth factor, beta receptor II (TGFBR2) [GenBank:D50683] -1.8 970.0 1760.5
TIMP metalloproteinase inhibitor 3 (TIMP3) [GenBank:NM_000362] -2.1 524.5 1067.1
Scaffold     
Collagen, type VI, alpha 1 (COL6A1) [GenBank:BE350145] 1.6 1125.6 767.4
Collagen, type VIII, alpha 2 (COL8A2) [GenBank:AI806793] -1.5 749.8 1067.1
Catenin, beta 1 (CTNNB1) [GenBank:AF130085] 1.8 1254.4 785.5
Dystonin (DST) [GenBank:BC004912] 1.8 1969.3 1178.2
Fibulin 1 (FBLN1) [GenBank:Z95331] -1.3 557.5 728.4
Fibronectin 1 (FN1) [GenBank:W73431] 3.5 1160.8 410.2
Homeobox A13 (HOXA13) [GenBank:BG289306 -2.1 30.5 62.8
Homeobox C6 (HOXC6) [GenBank:NM_004503] 1.8 857.2 525.7
Latent transforming growth factor beta binding protein 1 (LTBP1) [GenBank:AI986120] 1.6 997.6 646.6
Myocyte enhancer factor 2C (MEF2C) [GenBank:N22468] 1.7 * 498.1 296.5
Microfibrillar-associated protein 2 (MFAP2) [GenBank:NM_017459] -1.4 2875.4 4083.6
Tissue factor pathway inhibitor 2 TFPI2) [GenBank:AL574096] 2.8 76.2 38.3
Transforming growth factor, beta receptor I (TGFBR1) [GenBank:AV700621] 2.6 682.7 303.9
TIMP metalloproteinase inhibitor 3 (TIMP3) [GenBank:BF347089] -1.5 216.2 308.3
WNT1 inducible signaling pathway protein 3 (WISP3) [GenBank:AF143679] -2.0 318.5 549.8
  1. Genes were functionally filtered with regard to their association with skeletal development and extracellular matrix formation. For the complete list see Additional data file 1. * P < 0.05; ** P < 0.01; *** P < 0.001.