Table 4 Genes differentially expressed comparing chondrocytes in culture obtained from osteoarthritic (OA) and normal donors (ND)
Functional annotation Gene title (Gene symbol) | Accession number | Fold change | Signal | |
|---|---|---|---|---|
| Â | Â | OA vs ND | OA | ND |
Monolayer | Â | Â | Â | Â |
ADAM metalloproteinase with thrombospondin type 1 motif, 1 (ADAMTS1) | [GenBank:AF060152] | -1.7 | 968.0 | 1925.2 |
Collagen, type III, alpha 1 (COL3A1) | [GenBank:AU146808] | 2.2 | 564.3 | 258.7 |
Collagen, type V, alpha 3 (COL5A3) | [GenBank:AI984221] | 2.9 | 977.6 | 392.1 |
Collagen, type XI, alpha 1 (COL11A1) | [GenBank:BG028597] | 1.9 | 327.8 | 161.1 |
Cartilage link protein 1 (HAPLN1) | [GenBank:NM_001884] | 1.8 * | 2640.7 | 1467.5 |
Cartilage oligomeric matrix protein (COMP) | [GenBank:NM_000095] | -6.1 * | 24.7 | 187.4 |
Dystonin (DST) | [GenBank:BC004912] | -2.0 | 729.4 | 1486.6 |
Fibronectin 1 (FN1) | [GenBank:AJ276395] | -3.1 | 441.9 | 1642.6 |
Matrix metalloproteinase 1 (MMP1) | [GenBank:NM_002421] | 5.0 * | 857.0 | 200.5 |
Matrix metalloproteinase 2 (MMP2) | [GenBank:NM_004530] | -1.9 | 2300.1 | 3706.1 |
Matrix metalloproteinase 3 (MMP3) | [GenBank:NM_002422] | 2.6 | 2496.8 | 1052.8 |
Periostin, osteoblast specific factor (POSTN) | [GenBank:AY140646] | 1.9 | 6610.8 | 3544.5 |
SRY (sex determining region Y)-box 9 (SOX9) | [GenBank:AI382146] | -2.6 * | 123.0 | 281.2 |
Transforming growth factor, beta receptor II (TGFBR2) | [GenBank:D50683] | -1.8 | 970.0 | 1760.5 |
TIMP metalloproteinase inhibitor 3 (TIMP3) | [GenBank:NM_000362] | -2.1 | 524.5 | 1067.1 |
Scaffold | Â | Â | Â | Â |
Collagen, type VI, alpha 1 (COL6A1) | [GenBank:BE350145] | 1.6 | 1125.6 | 767.4 |
Collagen, type VIII, alpha 2 (COL8A2) | [GenBank:AI806793] | -1.5 | 749.8 | 1067.1 |
Catenin, beta 1 (CTNNB1) | [GenBank:AF130085] | 1.8 | 1254.4 | 785.5 |
Dystonin (DST) | [GenBank:BC004912] | 1.8 | 1969.3 | 1178.2 |
Fibulin 1 (FBLN1) | [GenBank:Z95331] | -1.3 | 557.5 | 728.4 |
Fibronectin 1 (FN1) | [GenBank:W73431] | 3.5 | 1160.8 | 410.2 |
Homeobox A13 (HOXA13) | [GenBank:BG289306 | -2.1 | 30.5 | 62.8 |
Homeobox C6 (HOXC6) | [GenBank:NM_004503] | 1.8 | 857.2 | 525.7 |
Latent transforming growth factor beta binding protein 1 (LTBP1) | [GenBank:AI986120] | 1.6 | 997.6 | 646.6 |
Myocyte enhancer factor 2C (MEF2C) | [GenBank:N22468] | 1.7 * | 498.1 | 296.5 |
Microfibrillar-associated protein 2 (MFAP2) | [GenBank:NM_017459] | -1.4 | 2875.4 | 4083.6 |
Tissue factor pathway inhibitor 2 TFPI2) | [GenBank:AL574096] | 2.8 | 76.2 | 38.3 |
Transforming growth factor, beta receptor I (TGFBR1) | [GenBank:AV700621] | 2.6 | 682.7 | 303.9 |
TIMP metalloproteinase inhibitor 3 (TIMP3) | [GenBank:BF347089] | -1.5 | 216.2 | 308.3 |
WNT1 inducible signaling pathway protein 3 (WISP3) | [GenBank:AF143679] | -2.0 | 318.5 | 549.8 |