From: Lessons from animal models of arthritis over the past decade
Model | Abbreviation | Speciesa | Feature | IC | T cell | References |
---|---|---|---|---|---|---|
Trigger-induced models | Â | Â | Â | Â | Â | Â |
   Non-specific immune stimuli |  |  |  |  |  |  |
Adjuvant-induced arthritis | AA | Lewis rat | Autoimmune | - | + | |
Oil-induced arthritis | OIA | DA rat | Autoimmune | - | + | [3] |
Pristane-induced arthritis | PIA | DA rat | Autoimmune | - | + | |
   Cartilage directed autoimmunity |  |  |  |  |  |  |
Collagen-induced arthritis | CIA | DBA mouse | CII AI | + | + | |
Proteoglycan-induced arthritis | PGIA | Balb/c mouse | PG AI | + | + | |
   Infectious agents/exogenous triggers |  |  |  |  |  |  |
Streptococcal cell wall arthritis | SCW-A | Lewis rat | Persistent bacteria AI | - | + | [10] |
Flare | SCW-F | Mouse | Th17 | - | + | [11] |
Antigen-induced arthritis | AIA | Rabbit, mouse | Persistent antigen | + | + | |
Flare | AIA-F | Mouse | Th17 | - | + | [14] |
Transgenic spontaneous models | Â | Â | Â | Â | Â | Â |
   HTLV-induced arthritis | HTLV | Mouse | Viral tax antigen | - | + | [15] |
   KRN arthritis | KRN | K/BxN mouse | GPI AI | + | + | |
   SKG arthritis | SKG | Mouse | ZAP-70 T cell defect | - | + | |
   GP130 arthritis | GP130 | Mouse | STAT3, T cell defect | - | + | |
   TNF transgenic arthritis | TNFtg | Mouse | TNF overexpression | - | - | |
   IL-1ra transgenic arthritis | IL-1ra-/- | Balb/c mouse | Autoimmune T cells | ± | + | [23] |
   IL-1 transgenic arthritis | IL-1tg | Mouse | IL-1 overexpression | - | - | [22] |
Immune complex models | Â | Â | Â | Â | Â | Â |
   Collagen type II | CAIA | DBA mouse | Mouse CII antibody | + | - | |
   KRN serum | GPI | Balb/c mouse | Mouse GPI antibody | + | - | [31] |
   Poly-L-lysine-lysozyme | PLL-L | DBA mouse | Cationic antigen | + | - | [28] |