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Table 1 Models of arthritis

From: Lessons from animal models of arthritis over the past decade

Model Abbreviation Speciesa Feature IC T cell References
Trigger-induced models       
   Non-specific immune stimuli       
Adjuvant-induced arthritis AA Lewis rat Autoimmune - + [1, 2]
Oil-induced arthritis OIA DA rat Autoimmune - + [3]
Pristane-induced arthritis PIA DA rat Autoimmune - + [4, 5]
   Cartilage directed autoimmunity       
Collagen-induced arthritis CIA DBA mouse CII AI + + [6, 7]
Proteoglycan-induced arthritis PGIA Balb/c mouse PG AI + + [8, 9]
   Infectious agents/exogenous triggers       
Streptococcal cell wall arthritis SCW-A Lewis rat Persistent bacteria AI - + [10]
Flare SCW-F Mouse Th17 - + [11]
Antigen-induced arthritis AIA Rabbit, mouse Persistent antigen + + [12, 13]
Flare AIA-F Mouse Th17 - + [14]
Transgenic spontaneous models       
   HTLV-induced arthritis HTLV Mouse Viral tax antigen - + [15]
   KRN arthritis KRN K/BxN mouse GPI AI + + [16, 17]
   SKG arthritis SKG Mouse ZAP-70 T cell defect - + [18, 19]
   GP130 arthritis GP130 Mouse STAT3, T cell defect - + [20, 21]
   TNF transgenic arthritis TNFtg Mouse TNF overexpression - - [47, 48]
   IL-1ra transgenic arthritis IL-1ra-/- Balb/c mouse Autoimmune T cells ± + [23]
   IL-1 transgenic arthritis IL-1tg Mouse IL-1 overexpression - - [22]
Immune complex models       
   Collagen type II CAIA DBA mouse Mouse CII antibody + - [26, 27]
   KRN serum GPI Balb/c mouse Mouse GPI antibody + - [31]
   Poly-L-lysine-lysozyme PLL-L DBA mouse Cationic antigen + - [28]
  1. aMost commonly used. AI = autoimmune; CAIA = collagen antibody-induced arthritis; GPI = glucose-6-phosphate isomerase; IC = immune complexes as an early feature; PG = proteoglycan.