Skip to main content

Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Nucleosome binding by serum amyloid P component from SLE patients

There is evidence in favor of apoptosis dysfunction being involved in the pathogenesis of SLE. Since mice deficient in the nucleosome-binding protein: serum amyloid P component (SAP) develop antinuclear immunity and nephritis it is possible that impaired clearance of nuclear material from apoptotic cells is the key defect. We therefore developed a solid-phase assay for the binding of SAP to nucleosomes and investigated the nucleosome binding characteristics of SAP from 20 different SLE patients as compared with normal donors. We could not demonstrate any significant differences between the groups and therefore the functions of other pentraxins (such as C-reactive protein) or DNA binding molecules (such as C1q) will be examined in future studies.

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Heegaard, N., Rahbek, L. & Recke, C. Nucleosome binding by serum amyloid P component from SLE patients. Arthritis Res Ther 3, P113 (2001). https://doi.org/10.1186/ar282

Download citation

Keywords

  • Public Health
  • Future Study
  • Apoptotic Cell
  • Nephritis
  • Normal Donor