Skip to main content

Table 2 Three-marker haplotype analysis of ITGAV single-nucleotide polymorphisms (rs10174098, rs3911238, rs3738919) in the Wellcome Trust Case Control Consortium, New Zealand and Oxford sample sets

From: The ITGAVrs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets

rs10174098

rs3911238

rs3738919

Case, number (frequency)

Control, number (frequency)

Pvalue

OR (95% CI)

WTCCC

      

   1

1

2

866 (0.261)

1,451 (0.275)

0.19

0.94 (0.85-1.03)

   2

1

1

858 (0.259)

1,382 (0.262)

0.82

0.99 (0.90-1.09)

   1

2

1

792 (0.239)

1,226 (0.232)

0.43

1.04 (0.94-1.16)

   1

1

1

524 (0.158)

741 (0.140)

0.021

1.15 (1.02-1.30)

   2

1

2

219 (0.066)

405 (0.077)

0.070

0.85 (0.72-1.01)

New Zealand

      

   1

1

2

357 (0.244)

260 (0.263)

0.29

0.90 (0.75~1.09)

   2

1

1

364 (0.249)

240 (0.243)

0.73

1.03 (0.86~1.25)

   1

2

1

359 (0.246)

223 (0.225)

0.26

1.12 (0.92~1.35)

   1

1

1

241 (0.165)

170 (0.172)

0.60

0.95 (0.76~1.17)

   2

1

2

110 (0.075)

73 (0.074)

0.91

1.02 (0.75~1.39)

Oxford, UK

      

   1

1

2

310 (0.256)

252 (0.253)

0.80

1.03 (0.85-1.24)

   2

1

1

306 (0.253)

262 (0.262)

0.67

0.96 (0.79-1.16)

   1

2

1

335 (0.277)

251 (0.252)

0.16

1.15 (0.95-1.39)

   1

1

1

158 (0.130)

162 (0.162)

0.04

0.78 (0.62-0.99)

   2

1

2

78 (0.064)

57 (0.057)

0.47

1.14 (0.80-1.62)

  1. Only haplotypes with frequency of at least 0.05 in controls are shown. CI, confidence interval; HWE, Hardy-Weinberg equilibrium; OR, odds ratio; WTCCC, Wellcome Trust Case Control Consortium.