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Table 4 Putative immune signature in SpA

From: Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles

   Set 1 Set 2  
Gene symbol Gene name Fold change Q (%) Fold change Q (%) Function
ALOX12* Arachidonate 12-lipoxygenase 1.7 2.4 1.9 2.1 Arachidonic acid metabolism; inflammatory response
BCL6* B-cell CLL/lymphoma 6 1.8 2.4 1.7 1.5 Pleiotropic action in immune response. Inhibits B cell apoptosis
CLU Clusterin 1.5 2.4 1.9 2.1 Complement regulatory action
CR1 Complement component (3b/4b) receptor 1 1.5 2.4 1.9 1.0 Complement receptor, regulates B cell apoptosis, immune complex clearance
DEFA4* Defensin, alpha 4, corticostatin 2.1 2.4 4.2 1.2 Non-specific immune response
FAM3B Family with sequence similarity 3, member B 4.9 2.4 3.6 1.0 IL1-like activity
GRB10* Growth factor receptor-bound protein 10 1.8 2.4 1.5 1.0 Regulator of nuclear factor kappa B (NFKB)
IL1R1* Interleukin 1 receptor type I 1.6 2.4 2.0 0.4 Binds to IL1
IL1R2* Interleukin 1 receptor, type II 1.6 2.4 1.8 1.5 Decoy target for IL1
MAPK14* Mitogen-activated protein kinase 14 1.5 2.4 1.6 1.8 Part of the MAPK cascade
NCR3 Natural cytotoxicity triggering receptor 3 -2.5 4.9 -1.7 1.5 Required for NK cell-mediated induction of dendritic cell maturation
NLRP2/NALP2* NLR family, pyrin domain containing 2 -2.5 4.3 -1.7 1.5 Part of the inflammasome; inhibits NFkB. Causes caspase-1 activation
PTGS1/COX1 Cyclooxygenase 1 1.9 2.4 1.8 2.1 Prostaglandin synthesis.
SELP Selectin P (CD62) 1.7 2.4 1.6 4.1 Extra-lymphoid T cell recruitment. Mediates Endothelial cell and leucocyte interaction
SLPI* Secretory leukocyte peptidase inhibitor 2.0 2.4 2.4 1.0 Antimicrobial activity; innate host defense mechanism
SOD2 Superoxide dismutase 2 1.7 2.4 2.8 1.5 Free radical scavenging enzyme involved in defense against oxidative stress
SPARC Secreted protein, acidic, cysteine-rich (osteonectin) 3.1 2.4 2.3 0.8 Involved in T cell activity and ossification
THBD* Thrombomodulin 1.5 2.4 1.7 3.1 Innate immune response activity
THBS1 Thrombospondin 1 2.0 2.4 2.0 2.5 Glycoprotein
TREM1 Triggering receptor expressed on myeloid cells-like 1 1.9 2.4 2.1 2.5 Amplifies response of NLRP2
  1. Significantly differentially expressed genes with a recognized immune or inflammation-related function present in Set 1 and Set 2. Functional annotations were obtained from Online Mendelian Inheritance in Man database [32]. *Secondary analysis indicates that expression level changes are more apparent in males.