Table 4 Putative immune signature in SpA

ALOX12*

Arachidonate 12-lipoxygenase

1.7

2.4

1.9

2.1

Arachidonic acid metabolism; inflammatory response

BCL6*

B-cell CLL/lymphoma 6

1.8

2.4

1.7

1.5

Pleiotropic action in immune response. Inhibits B cell apoptosis

CLU

Clusterin

1.5

2.4

1.9

2.1

Complement regulatory action

CR1

Complement component (3b/4b) receptor 1

1.5

2.4

1.9

1.0

Complement receptor, regulates B cell apoptosis, immune complex clearance

DEFA4*

Defensin, alpha 4, corticostatin

2.1

2.4

4.2

1.2

Non-specific immune response

FAM3B

Family with sequence similarity 3, member B

4.9

2.4

3.6

1.0

IL1-like activity

GRB10*

Growth factor receptor-bound protein 10

1.8

2.4

1.5

1.0

Regulator of nuclear factor kappa B (NFKB)

IL1R1*

Interleukin 1 receptor type I

1.6

2.4

2.0

0.4

Binds to IL1

IL1R2*

Interleukin 1 receptor, type II

1.6

2.4

1.8

1.5

Decoy target for IL1

MAPK14*

Mitogen-activated protein kinase 14

1.5

2.4

1.6

1.8

Part of the MAPK cascade

NCR3

Natural cytotoxicity triggering receptor 3

-2.5

4.9

-1.7

1.5

Required for NK cell-mediated induction of dendritic cell maturation

NLRP2/NALP2*

NLR family, pyrin domain containing 2

-2.5

4.3

-1.7

1.5

Part of the inflammasome; inhibits NFkB. Causes caspase-1 activation

PTGS1/COX1

Cyclooxygenase 1

1.9

2.4

1.8

2.1

Prostaglandin synthesis.

SELP

Selectin P (CD62)

1.7

2.4

1.6

4.1

Extra-lymphoid T cell recruitment. Mediates Endothelial cell and leucocyte interaction

SLPI*

Secretory leukocyte peptidase inhibitor

2.0

2.4

2.4

1.0

Antimicrobial activity; innate host defense mechanism

SOD2

Superoxide dismutase 2

1.7

2.4

2.8

1.5

Free radical scavenging enzyme involved in defense against oxidative stress

SPARC

Secreted protein, acidic, cysteine-rich (osteonectin)

3.1

2.4

2.3

0.8

Involved in T cell activity and ossification

THBD*

Thrombomodulin

1.5

2.4

1.7

3.1

Innate immune response activity

THBS1

Thrombospondin 1

2.0

2.4

2.0

2.5

Glycoprotein

TREM1

Triggering receptor expressed on myeloid cells-like 1

1.9

2.4

2.1

2.5

Amplifies response of NLRP2