Inhibition of IL-1-induced loss of meniscal explant dynamic (a) compression and (b) shear moduli by metalloproteinase inhibitors. Explants from day 0 and 12 were tested in oscillatory unconfined compression and torsional shear. Data are mean + standard error of the mean, n = 6. ‡ indicate P < 0.05 vs. IL-1. MMP = matrix metalloproteinase.