Table 2 Results in outcome variables at entry and at 12 and 24 weeks
Outcome variables | CCII | Pvaluea | MTX | Pvaluea | Pvalueb |
|---|---|---|---|---|---|
Pain (VAS) | Â | Â | Â | Â | Â |
   Entry | 6.02 ± 1.43 |  | 5.91 ± 1.76 |  | >0.05 |
   12 weeks | 4.59 ± 2.22 | <0.01 | 4.09 ± 1.99 | <0.01 | >0.05 |
   24 weeks | 3.58 ± 2.55 | <0.01 | 3.38 ± 2.35 | <0.01 | <0.05 |
Morning stiffness, minutes | Â | Â | Â | Â | Â |
   Entry | 99.26 ± 25.14 |  | 104.89 ± 26.42 |  | >0.05 |
   12 weeks | 62.66 ± 25.06 | <0.01 | 45.83 ± 21.28 | <0.01 | <0.01 |
   24 weeks | 36.12 ± 17.21 | <0.01 | 33.98 ± 12.59 | <0.01 | >0.05 |
Tender joint count | Â | Â | Â | Â | Â |
   Entry | 13.34 ± 6.43 |  | 14.09 ± 6.82 |  | >0.05 |
   12 weeks | 9.14 ± 6.67 | <0.01 | 8.78 ± 6.01 | <0.01 | >0.05 |
   24 weeks | 6.34 ± 4.81 | <0.01 | 7.22 ± 6.91 | <0.01 | >0.05 |
Swollen joint count | Â | Â | Â | Â | Â |
   Entry | 10.38 ± 6.63 |  | 10.57 ± 7.25 |  | >0.05 |
   12 weeks | 6.89 ± 5.46 | <0.01 | 5.63 ± 4.97 | <0.01 | <0.01 |
   24 weeks | 4.26 ± 2.03 | <0.01 | 4.38 ± 2.94 | <0.01 | >0.05 |
HAQ | Â | Â | Â | Â | Â |
   Entry | 0.82 ± 0.56 |  | 0.86 ± 0.55 |  | >0.05 |
   12 weeks | 0.65 ± 0.41 | <0.01 | 0.51 ± 0.42 | <0.01 | <0.01 |
   24 weeks | 0.43 ± 0.27 | <0.01 | 0.44 ± 0.21 | <0.01 | <0.05 |
Physician's assessment (VAS) | Â | Â | Â | Â | Â |
   Entry | 5.83 ± 1.54 |  | 5.78 ± 1.26 |  | >0.05 |
   12 weeks | 4.68 ± 2.09 | <0.01 | 4.03 ± 2.06 | <0.01 | <0.01 |
   24 weeks | 3.81 ± 1.52 | <0.01 | 3.53 ± 1.64 | <0.01 | >0.05 |
Patient's assessment (VAS) | Â | Â | Â | Â | Â |
   Entry | 6.01 ± 1.51 |  | 6.06 ± 1.71 |  | >0.05 |
   12 weeks | 4.86 ± 2.01 | <0.01 | 4.31 ± 2.06 | <0.01 | <0.01 |
   24 weeks | 3.92 ± 2.45 | <0.01 | 3.71 ± 2.04 | <0.01 | <0.05 |
ESRc, mm/hour | Â | Â | Â | Â | Â |
   Entry | 38.18 ± 17.58 |  | 42.51 ± 19.37 |  | >0.05 |
   12 weeks | 38.03 ± 14.17 | >0.05 | 35.84 ± 13.24 | <0.01 | <0.01 |
   24 weeks | 37.53 ± 10.22 | >0.05 | 34.21 ± 15.25 | <0.01 | <0.01 |
C-reactive protein, mg/L | Â | Â | Â | Â | Â |
   Entry | 17.52 ± 8.27 |  | 23.24 ± 9.81 |  | >0.05 |
   12 weeks | 17.27 ± 15.14 | >0.05 | 16.01 ± 13.41 | <0.01 | <0.05 |
   24 weeks | 15.56 ± 12.38 | >0.05 | 15.08 ± 12.25 | <0.01 | <0.05 |
Rheumatoid factor, U/mL | Â | Â | Â | Â | Â |
   Entry | 203.65 ± 61.95 |  | 198.99 ± 21.31 |  | >0.05 |
   24 weeks | 150.21 ± 16.18 | >0.05 | 123.35 ± 11.32 | >0.05 | >0.05 |