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Figure 2 | Arthritis Research & Therapy

Figure 2

From: RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies

Figure 2

Lumbar vertebrae from nonarthritic control and vehicle-treated adjuvant-induced arthritis and collagen-induced arthritis rats. Representative photomicrographs of lumbar vertebrae from nonarthritic control and vehicle (Veh) (PBS)-treated adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) rats. The trabeculae beneath the physeal plate (pale vertical column at the left margin) were attenuated in arthritic animals but the bone marrow composition and density - including the population of subphyseal osteoclasts (brown cells, cathepsin K-positive) - were equivalent among nonarthritic and arthritic animals. Stain: immunohistochemistry for cathepsin K with H & E counterstain. Magnification: ×100.

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Arthritis Research & Therapy

ISSN: 1478-6362

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