Skip to main content
Figure 7 | Arthritis Research & Therapy

Figure 7

From: RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies

Figure 7

Linear regression analyses of serum cytokines versus local bone loss or local inflammation. (a) to (d) Bone loss was quantified as the percentage change in areal bone mineral density (BMD) from the day of onset for clinical arthritis (day 0) to day 14 post onset. (e) and (f) Paw swelling was quantified as the percentage change from day 4 post onset (treatment initiation) to day 14 post onset. Serum receptor activator of NF-κB ligand (RANKL) and IL-1β were evaluated on day 14 post onset. Open circles, nonarthritic controls + vehicle; black circles, arthritis + vehicle; open triangles, arthritis + IL-1 receptor antagonist; grey diamonds, arthritis + PEGylated soluble TNF receptor type I; grey circles, arthritis + OPG-Fc. n = 8/group. AIA, adjuvant-induced arthritis; CIA, collagen-induced arthritis.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us