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Table 1 Histological evaluation of inflammation in rat hind paws

From: RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies

Treatment group

Inflammation score

 

Adjuvant-induced arthritis

Collagen-induced arthritis

Nonarthritis control

0†,‡

0†,‡

Arthritis + vehicle

3.8 ± 0.1*

3.1 ± 0.1*

Arthritis + PEGylated soluble TNF receptor type I

3.6 ± 0.3*

2.0 ± 0.3* ,†,‡

Arthritis + IL-1 receptor antagonist

3.8 ± 0.2*

1.2 ± 0.1* ,†,‡

Arthritis + osteoprotegerin-Fc

3.8 ± 0.2*

3.4 ± 0.2*

  1. Data represent mean ± standard error of the means, n = 8/group. *Significantly different from control (nonarthritic) rats, P < 0.05. Significantly different from vehicle-treated arthritic rats, P < 0.05. Significantly different from osteoprotegerin-treated arthritic rats, P < 0.05.