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Table 1 Histological evaluation of inflammation in rat hind paws

From: RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies

Treatment group Inflammation score
  Adjuvant-induced arthritis Collagen-induced arthritis
Nonarthritis control 0†,‡ 0†,‡
Arthritis + vehicle 3.8 ± 0.1* 3.1 ± 0.1*
Arthritis + PEGylated soluble TNF receptor type I 3.6 ± 0.3* 2.0 ± 0.3* ,†,‡
Arthritis + IL-1 receptor antagonist 3.8 ± 0.2* 1.2 ± 0.1* ,†,‡
Arthritis + osteoprotegerin-Fc 3.8 ± 0.2* 3.4 ± 0.2*
  1. Data represent mean ± standard error of the means, n = 8/group. *Significantly different from control (nonarthritic) rats, P < 0.05. Significantly different from vehicle-treated arthritic rats, P < 0.05. Significantly different from osteoprotegerin-treated arthritic rats, P < 0.05.