Figure 6

T-cell phenotyping in arthritic mice treated with Rac1 carboxy-terminal peptide. Blood (a) and spleens (b) were obtained from arthritic mice treated with Ctrl or Rac1 peptide (2 mg, n = 5 per group), and cells were stained with antibodies against CD3, CD4, CD8, CD44, and CD62L. The percentages of CD3⁺ T cells expressing CD4 and CD8 (left panels) and naïve (CD44^-CD62L⁺), central memory (CM) (CD44⁺CD62L⁺), and effector/memory (EM) (CD44⁺CD62L^-) CD3⁺CD4⁺ (middle panels) and CD3⁺CD8⁺ T cells were calculated. Data points within each column represent individual mice, and the bar indicates the median value. *P ≤ 0.05, *P ≤ 0.01. Ctrl, control.