Table 1 Characteristics of participants
| Â | With BMLs at baseline (n = 37) | Free of BMLs at baseline (n = 234) | ||||
|---|---|---|---|---|---|---|
| Â | BMLs persisted (n = 20) | BMLs resolved (n = 17) | Pvalue | BMLs developed (n = 33) | No BMLs developed (n = 201) | Pvalue |
Age (years) | 58.6 (5.5) | 57.8 (6.4) | 0.701 | 57.7 (5.9) | 57.8 (5.0) | 0.901 |
Gender (% female) | 13 (65%) | 11 (65%) | 0.982 | 23 (70%) | 122 (61%) | 0.302 |
Body mass index (kg/m2) | 25.9 (3.9) | 24.8 (4.1) | 0.501 | 28.0 (5.1) | 25.4 (3.7) | 0.011 |
Annual change in cartilage volume (μl) |  |  |  |  |  |  |
   Medial tibial | 36.0 (39.2) | 10.5 (45.9) | 0.131 | 34.0 (54.6) | 19.5 (50.0) | 0.081 |
   Lateral tibial | 25.6 (67.2) | 28.4 (42.1) | 0.081 | 37.6 (57.0) | 21.0 (48.4) | 0.881 |
Progression of tibiofemoral cartilage defects, number (%) | Â | Â | Â | Â | Â | Â |
   Medial | 7 (35%) | 3 (18%) | 0.152 | 11 (33%) | 44 (21%) | 0.242 |
   Lateral | 9 (18%) | 8 (47%) | 0.0082 | 15 (45%) | 47 (23%) | 0.902 |