Figure 3

Cells that express intermediate levels of CD16 (CD16^int) are found in vivo in human PBMC. (a) CD16 expression on human peripheral blood mononuclear cells (PBMC) is heterogeneous. The data shown here are the representatives of CD16 expression patterns on fresh human PBMC from 82 subjects. [a] PBMC that expressed high and low levels of CD16 without the CD16^int population. [b to d] PBMC that have CD16^int populations with different CD16 expression levels. (b) Ex vivo analysis of CD14 and CD16 expression. Representative examples of individuals [a] without a CD16^int population, [b] CD14- CD16^int (arrow) cells and [c] CD14+ CD16^int (arrow) cells are shown. In total, 16 healthy control (HC), 29 psoriasis (Ps), 29 psoriatic arthritis (PsA), and 8 rheumatoid arthritis (RA)patients were included in this analysis. See Table 1 for the summary of CD16^int percentage in HC, Ps, PsA and RA groups.