Figure 2

Histopathological examination of osteoarthritic changes in mouse knee (femoro-tibial) joints following medial meniscal destabilization (MMD). (a) Progressive cartilage damage at 2, 4, 8 and 16 weeks following medial meniscal destabilization-induced osteoarthritis (OA) in mouse knee joints. Toluidine blue/fast green stained paraffin sections. Scale bar = 200 μm. (b) Serial sections stained with toluidine blue or with S100A8 immunolocalization in mouse knees at different times following medial meniscal destabilization (MMD) or sham surgery (at 16 weeks). Scale bar = 100 μm. Negative control sections were immunostained using an equivalent concentration of rabbit IgG.