Skip to main content
Figure 3 | Arthritis Research & Therapy

Figure 3

From: B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin

Figure 3

(a) Biologic activity and (b) neutralization of BLyS/APRIL HTs compared with those of BLyS and APRIL in TACI-Jurkat proliferation assays. APRIL, a proliferation-inducing ligand; BAFF-R, BAFF receptor; BCMA, B cell-maturation antigen; BLyS, B-lymphocyte stimulator; EC50, 50% effective concentration; HT, heterotrimer; IC50, 50% inhibition concentration; Ig, immunoglobulin; nz, trypsinized trimer without the "zipper" domain; TACI, transmembrane activator and CAML interactor; zz, trimer containing the "zipper" trimerization domain.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us