Figure 1

Potentiation by PDGF alone, TGF-β alone, or their combination (2GF), of (a) IL6 and (b) MMP3 secretion from FLS. FLS were cultured for 24 hours with TNFα (10 ng/ml) or IL1β (2 ng/ml), and/or growth factors (10 ng/ml), and supernatants analyzed by ELISA. Mean & SEM, n = 3 RA FLS lines. Asterisk indicates P < 0.05 between the combination and the added values for TNF alone and growth factor alone by Students' t-test.