Table 2 Association of rs1805010 and rs1801275 with rheumatoid nodules after stratification by the presence of HLA-DRB1 SE and autoantibodies in African Americans with RA
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Rheumatoid nodules n(%) | No rheumatoid nodules n(%) | Crude OR (95% CI) | P | Adjustedb OR (95% CI) | P | |
rs1805010, n (%) | n = 51a | n = 171a | ||||
AA | 17 (33.3) | 31 (18.1) | 1.61 (0.69 to 3.75) | 0.27 | 2.74 (0.80 to 9.41) | 0.11 |
AG | 20 (39.2) | 99 (57.9) | 0.59 (0.27 to 1.28) | 0.18 | 0.64 (0.21 to 1.96) | 0.43 |
GG | 14 (27.5) | 41 (24.0) | 1.00 | -- | 1.00 | |
rs1801275, n (%) | n = 51a | n = 172a | ||||
AA | 7 (13.7) | 14 (8.1) | 2.44 (0.86 to 6.95) | 0.09 | 8.08 (1.60 to 40.89) | 0.01 |
AG | 27 (52.9) | 75 (43.6) | 1.76 (0.89 to 3.48) | 0.11 | 2.97 (1.08 to 8.17) | 0.04 |
GG | 17 (33.3) | 83 (48.3) | 1.00 | -- | 1.00 | -- |