Skip to main content

Table 3 Autoantibodies, endothelial cell parameters, FMD, NMD and IMT in MCTD patients with/without cardiovascular diseases

From: Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease

Feature MCTD (n = 50) Controls (n = 38) Pvalue, MCTD vs. controlsa MCTD/CVD+ (n = 23) MCTD/CVD- (n = 27) Pvalue, MCTD/CVD+ vs. MCTD/CVD-b
Anti-U1RNP (U/ml) 20.18 ± 14.6 8.02 ± 3.5 <0.001 30.3 ± 14.6 11.51 ± 7.28 <0.001
Anti-CL IgG/IgM (U/ml) 13.98 ± 12.2 6.06 ± 2.93 <0.001 21.02 ± 15.04 7.98 ± 2.95 <0.001
AECA (IU/ml) 50.1 ± 34.5 17.1 ± 8.48 <0.001 62.9 ± 26.3 39.1 ± 37.2 <0.001
Thrombomodulin (ng/ml) 12.2 ± 8.1 3.2 ± 1.3 <0.001 15.9 ± 5.2 9.0 ± 8.8 <0.001
vWFAg (%) 224.1 ± 115 89.4 ± 27.1 <0.001 311.5 ± 72.0 149.7 ± 90.0 <0.001
FMD (%) 4.76 ± 4.2 8.74 ± 5.05 <0.001 3.54 ± 2.9 5.81 ± 4.87 0.0002
NMD (%) 14.35 ± 6.67 17.16 ± 6.7 0.073 13.54 ± 6.06 15.03 ± 7.15 0.1283
IMT (mm) 0.64 ± 0.13 0.53 ± 0.14 <0.001 0.72 ± 0.11 0.57 ± 0.1 <0.001
  1. AECA, anti-endothelial cell antibody; anti-CL, anti-cardiolipin; anti-U1RNP, anti-U1 ribonucleoprotein; CVD, cardiovascular disease; FMD, flow-mediated dilation; IMT, intima-media thickness; MCTD, mixed connective tissue disease; NMD, nitrate-mediated dilation; vWFAg, von Willebrand factor antigen. aMCTD and controls, Mann-Whitney U test. bMCTD/CVD+ and MCTD/CVD-, analysis of variance test.