The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study

Table 3 Associations between body composition and hip JSN in women

	Multivariable^a		Multivariable^b		Multivariable^c
	β (CI)	P	β (CI)	P	β (CI)	P
Superior JSN
BMI (grade per kg/m²)	0.11 (0.03 to 0.19)	0.009	-0.01 (-0.16 to 0.14)	0.874	0.11 (0.03 to 0.19)	0.009
WHR (grade per 100%)	6.86 (-0.36 to 14.07)	0.063	2.69 (-5.05 to 10.42)	0.496	6.04 (-1.05 to 13.14)	0.095
Trunk fat (grade per 100%)	12.61 (5.35 to 19.87)	0.001	7.06 (-3.57 to 17.69)	0.193	11.80 (4.53 to 19.07)	0.001
Total fat (grade per 100%)	13.17 (3.65 to 22.70)	0.007	3.40 (-11.19 to 17.99)	0.648	12.10 (2.60 to 21.60)	0.013
Axial JSN
BMI (grade per kg/m²)	0.08 (-0.01 to 0.16)	0.071	-0.12 (-0.28 to 0.05)	0.174	0.07 (-0.01 to 0.16)	0.084
WHR (grade per 100%)	8.77 (1.39 to 16.14)	0.020	4.88 (-2.88 to 12.64)	0.218	7.58 (0.55 to 14.62)	0.034
Trunk fat (grade per 100%)	8.10 (1.53 to 14.66)	0.016	-0.65 (-10.42 to 9.11)	0.896	6.66 (0.03 to 13.29)	0.049
Total fat (grade per 100%)	7.93 (-0.62 to 16.48)	0.069	-7.18 (-19.50 to 5.14)	0.253	5.64 (-2.79 to 14.08)	0.190

^aAdjusted for age, height, ever smoked, diabetes, rheumatoid arthritis, heart disease, and asthma. ^bFurther adjusted for leptin or ^cfurther adjusted for interleukin-6. Dependent variable, JSN grade (0-2) in superior or axial compartment. Independent variable, BMI, WHR, trunk fat, or total fat (all except BMI expressed as percentages between 0 and 100%). IL-6, interleukin-6; CI, confidence interval; JSN, joint-space narrowing; BMI, body mass index; WHR, waist-to-hip ratio.

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