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Table 2 Prevalence of anti-CENP-A and anti-CENP-B autoantibodies by ELISA in different disease cohorts

From: Clinical and serological evaluation of a novel CENP-A peptide based ELISA

 

CENP-A

   

CENP-B

    
 

No. (%) >1.0 RU

No. (%) >1.5 RU

Mean/Median RU

Min/Max RU

No. (%) >1.0 RU

No. (%) >1.5 RU

Mean/Median RU

Min/Max RU

t-test CENP-B vs. A

SSc (n = 131)

64 (48.9)

48 (36.6)

2.37/0.98

0.1/7.9

53 (40.5)

49 (37.4)

2.77/0.47

0.2/9.6

P = 0.27

SLE (n = 109)

18 (16.5)

4 (3.7)

0.62/0.46

0.1/5.2

21 (19.3)

6 (5.5)

0.81/0.66

0.2/6.3

P = 0.027*

RA (n = 15)

0 (0.0)

0 (0.0)

0.29/0.26

0.1/0.5

0 (0.0)

0 (0.0)

0.51/0.49

0.3/0.9

P = 0.0002*

Other SARD (n = 10)

0 (0.0)

0 (0.0)

0.34/0.26

0.1/0.8

1 (10.0)

1 (10.0)

0.71/0.61

0.3/1.6

P = 0.024*

Controls all (n = 134)

18 (13.4)

4 (3.0)

0.56/0.43

0.1/5.2

22 (16.4)

7 (5.2)

0.76/0.61

0.2/6.3

P = 0.0047*

  1. CENP: centromere protein; RA: rheumatoid arthritis; RU: relative units; SARD: systemic autoimmune rheumatic disease; SLE: systemic lupus erythematosus; SSc: systemic sclerosis