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Table 2 Potential targets and drugs for pharmacological intervention in posttraumatic arthritis

From: New developments in osteoarthritis: Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

Target

Drugs

References

Caspases

Small molecule inhibitors

[59, 60, 63, 64]

Proinflammatory cytokines (TNFα, IL-1, IL-6)

Neutralizing antibodies, IL-converting enzyme, TACE inhibitors

[66–70]

Cartilage repair

Growth factors (BMP-7, FGF-2, FGF-18, IGF-1)

[75–83]

Matrix-degrading enzymes (matrix metalloproteinases, aggrecanases, cysteine-dependent cathepsins, neutrophil-derived enzymes)

Small-molecule inhibitors, TIMP

[14]

Oxygen radicals

SOD, SOD mimetics

[84–87]

Lubricant deficiency

Lubricin, hyaluronan

[92, 93]

Anti-inflammatory cytokines

 

[71–74]

  1. SOD, superoxide dismutase; TACE, TNFα converting enzyme; TIMP, tissue inhibitors of metalloproteinases.
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Arthritis Research & Therapy

ISSN: 1478-6362

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