Figure 2

Mean change in modified total Sharp score for C-reactive protein subgroups. Changes in modified total Sharp score (ΔmTSS) from baseline to week 24 with standard error were determined for patients grouped post hoc by (a) baseline C-reactive protein (CRP) categorized as < 1 mg/dl and ≥1 mg/dl, (b) baseline C-reactive protein (CRP) categorized as ≤0.287 mg/dl, > 0.287 to < 1 mg/dl, ≥1.0 to < 2.0 mg/dl, and ≥2 mg/dl, and (c) 24-week time-averaged CRP categorized as ≤0.287 mg/dl, > 0.287 to < 1 mg/dl, ≥1.0 to < 2.0 mg/dl, and ≥2 mg/dl. (d) Mean CRP values at baseline and week 24, with standard error, were determined for patients grouped according to whether they had radiographic progression (ΔmTSS > 0.5) between baseline and week 24. Data are observed; except for CRP values in (c), which used the last observation carried forward for missing values. *P < 0.05, **P < 0.01, ***P ≤0.001, †P = 0.052 vs. placebo.