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Table 2 Univariate analyses of predictors for radiographic progression

From: Risk factors for radiographic progression in psoriatic arthritis: subanalysis of the randomized controlled trial ADEPT

 

Placebo-treated patients

Adalimumab-treated patients

All patients

 

OR

95% CI

Pvalue

OR

95% CI

Pvalue

OR

95% CI

Pvalue

Treatment with adalimumaba

NA

NA

NA

NA

NA

NA

0.24

0.13, 0.48

< 0.001

CRP (time-averaged)

1.74

1.33, 2.28

< 0.001

1.48

0.99, 2.22

0.058

1.84

1.47, 2.30

< 0.001

CRP (continuous)

1.40

1.12, 1.75

0.003

1.05

0.84, 1.31

0.684

1.18

1.03, 1.35

0.017

CRP > 0.287 mg/dla

5.50

1.59, 19.09

0.007

3.12

0.39, 25.02

0.285

4.25

1.47, 12.24

0.007

CRP (1.0 mg/dla

3.98

1.90, 8.32

< 0.001

3.51

1.08, 11.39

0.036

3.82

2.09, 6.99

< 0.001

CRP (2.0 mg/dla

4.40

2.05, 9.45

< 0.001

1.34

0.34, 5.23

0.676

3.46

1.87, 6.42

< 0.001

Age

1.00

0.97, 1.03

0.954

1.02

0.97, 1.07

0.399

1.01

0.98, 1.04

0.484

RF-positivea

1.45

0.46, 4.60

0.530

1.65

0.33, 8.27

0.542

1.41

0.57, 3.49

0.458

Swollen joint count

1.02

0.99, 1.06

0.122

1.01

0.97, 1.06

0.657

1.02

1.00, 1.04

0.100

Tender joint count

1.00

0.98, 1.02

0.741

1.01

0.98, 1.04

0.459

1.01

0.99, 1.02

0.358

mTSS

1.03

1.01, 1.04

< 0.001

1.00

0.995, 1.01

0.365

1.01

1.00, 1.02

0.001

Joint erosion

1.05

1.02, 1.08

< 0.001

1.01

0.99, 1.02

0.490

1.02

1.01, 1.03

0.001

Joint space narrowing

1.05

1.03, 1.08

< 0.001

1.01

0.99, 1.03

0.264

1.02

1.01, 1.04

0.001

Methotrexate (yes)a

1.37

0.67, 2.77

0.387

2.15

0.63, 7.33

0.222

1.47

0.82, 2.64

0.201

PsA duration

1.00

0.96, 1.04

0.816

1.03

0.97, 1.10

0.337

1.00

0.97, 1.04

0.896

Psoriasis duration

0.97

0.93, 0.998

0.039

1.03

0.99, 1.08

0.140

0.99

0.96, 1.01

0.277

Weight

1.01

0.99, 1.03

0.450

1.00

0.97, 1.03

0.848

1.00

0.99, 1.02

0.717

  1. CI, confidence interval; CRP, C-reactive protein; mTSS, modified total Sharp score; NA, not applicable; OR, odds ratio; PsA, psoriatic arthritis; RF, rheumatoid factor. All variables are at baseline, except CRP (time-averaged). aDichotomous variables - those without a footnote annotation are continuous variables.